Inventors:
- Cincinnati OH, US
Jose Carlos GARCIA-GARCIA - Cincinnati OH, US
George Franklin GERBERICK - Cincinnati OH, US
John August WOS - Mason OH, US
David Thomas STANTON - Hamilton OH, US
Thomas Alfred INGLIN - Loveland OH, US
Michael REILLY - Lebanon OH, US
Angela Jane DEUTSCH - West Chester OH, US
Jodie Michele REED - Loveland OH, US
David Blair CODY - West Harrison IN, US
International Classification:
A61K 31/26
A61K 31/351
A61K 31/5375
A61K 31/4453
A61K 45/06
A61K 31/27
Abstract:
The invention provides one or more methods of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I):wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.