US Patent:
20080207555, Aug 28, 2008
Inventors:
Joel Moss - Bethesda MD, US
Shunya Oka - Niigata, JP
Jiro Kato - Rockville MD, US
Jianfeng Zhu - Frederick MD, US
Atsushi Kasamatsu - Rockville MD, US
International Classification:
A61K 31/70
C12P 19/00
C12P 21/04
C12N 5/06
C12N 15/87
A61P 43/00
C12Q 1/68
C12Q 1/02
C12Q 1/34
US Classification:
514 44, 435 72, 435 691, 435375, 435455, 435 6, 435 29, 435 18
Abstract:
This disclosure provides methods for catalyzing the release of ADP-ribose from poly(ADP-ribose) or O-acetyl-ADP-ribose. Also provided are methods for modifying DNA repair or chromatin structure by introducing into the cell an agent that modifies the activity of an ARH3 polypeptide, or variant or fragment thereof. Further provided are methods for screening molecules involved in the poly(ADP-ribosyl)ation of proteins or O-acetyl-ADP-ribose content, and method for treating disorders by altering activity of an ARH3 protein.