Jing Hui Liu

20100323393, Dec 23, 2010

Jun 22, 2010

12/820933

Xiuli An - Bayside NY, US
Mohandas Narla - New York NY, US
Jing Liu - Woodside NY, US
Susanne Heck - Bronx NY, US

C12Q 1/06
C12N 5/078
C12Q 1/02
C12Q 1/04

435 39, 435325, 435 29, 435 34

Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors.

20120295285, Nov 22, 2012

Jul 13, 2012

13/548761

Xiuli An - Bayside NY, US
Mohandas Narla - New York NY, US
Jing Liu - Woodside NY, US
Susanne Heck - Bronx NY, US

NEW YORK BLOOD CENTER, INC. - New York NY

C12Q 1/04
G01N 21/64
G01N 33/566
C12Q 1/06

435 725, 435 34, 435 39

Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors.

20130017250, Jan 17, 2013

Jul 16, 2012

13/550567

Henry Ginsberg - Dobbs Ferry NY, US
Jing Liu - New York NY, US

The Trustees of Columbia University in the City of New York - New York City NY

A61K 38/44
G01N 21/76
A61P 3/10
C07H 21/04
A61K 9/127
A61P 9/00
G01N 21/17
G01N 21/64

424450, 435 29, 435 8, 424 944, 536 241

It was discovered that insulin binding to insulin receptors signals the upregulation of expression of the liver enzyme deiodinase 1 (Dio1), which in turn activates the ApoA-1 promoter, thereby thereby increasing ApoA-1 expression (primarily in the liver), that in turn raises the levels of plasma ApoA-1, the major and necessary protein in HDLC. Certain embodiments of the invention are directed to methods for increasing circulating HDLC levels in an animal by administering therapeutically effective amounts of Dio1, or by increasing the level of Dio1 through gene therapy.

20130122535, May 16, 2013

Nov 9, 2012

13/673296

President and Fellows of Harvard College - Cambridge MA, US
Jing Liu - Brookline MA, US

President and Fellows of Harvard College - Cambridge MA

C12Q 1/02

435 29, 536 2722, 530409, 435325

Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms. Described herein are robust chemical methods for imaging and affinity-purifying nascent polypeptides in cells and in animals, based on puromycin analogs. Puromycin analogs of the present invention form covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the proteasome and can be visualized and specifically captured by a bioorthogonal reaction (e.g., [3+2]cycloaddition). The methods of the present invention have broad applicability for imaging protein synthesis and for identifying proteins synthesized under various physiological and pathological conditions in vivo.

56291566, May 13, 1997

Dec 29, 1994

8/366422

Jyotsna Shah - Nashua NH
Walter King - Andover MA
Jing Liu - Waltham MA
James Smith - Shrewsbury MA
Eugene Serpe - Winston-Salem NC
Sonya Popoff - Wayland MA

Amoco Corporation - Chicago IL

C12Q 168
C12P 1934

435 6

New methods for performing sandwich assays have been discovered. The assays utilize dual capture probes and eliminate noise resulting from nonspecific binding of detector probe to capture probe.

58495045, Dec 15, 1998

May 26, 1995

8/452145

Jyotsna Shah - Nashua NH
Amelia Buharin - St. Paul MN
David J. Lane - Milford MA
Jing Liu - Waltham MA

Amoco Corporation - Chicago IL

G01N 3353
C07H 2104
A61K 5100

435 72

The invention features nucleic acid probes and methods for detecting Pneumocystis carinii (e. g. , human or ferret P. carinii) in hybridization assays.

55213006, May 28, 1996

Aug 13, 1991

7/744282

Jyotsna S. Shah - Nashua NH
Ray M. Nietupski - Millbury MA
Jing Liu - Framingham MA

Norval B. Galloway

C07H 2102
C07H 2104

536 2432

Disclosed are nucleic acid oligonucleotides which are substantially complementary to nucleic acids from Mycobacteria, and subgeneric classes thereof. More specifically, the oligonucleotides are complementary to ribosomal RNA (rRNA) and the DNA encoding rRNA (rDNA). Uses for such oligonucleotides include detection of Mycobacteria by hybridization and amplification of Mycobacterial nucleic acid by polymerase chain reaction.

20220348580, Nov 3, 2022

Jun 21, 2019

17/254345

- New York NY, US
- Chapel Hill NC, US
Jing Liu - New York NY, US
Xufen Yu - New York NY, US
Dongxu Li - Chapel Hill NC, US

C07D 487/04
C07D 401/14
C07D 417/14

Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.