Jie Li

20090144381, Jun 4, 2009

Nov 6, 2008

12/289924

Jie Li - Mountainside NJ, US
David Tazartes - New York NY, US
Yukun Gou - Wayne PA, US

Barclays Capital Inc. - New York NY

G06F 15/16

709206

A system includes a data store and a server in communication with the data store. The server includes formatting modules having a plurality of formatters, validation modules having a plurality of validators, and a streaming module. The server is configured to receive messages containing financial transaction data from one or more electronic communication networks or one or more client devices. The formatters are configured for each of the electronic communication networks or client devices and convert the messages into an internal format of the streaming system. The validation modules are configured to perform a validation check on the one or more formatted messages.

20180369159, Dec 27, 2018

Dec 14, 2016

16/063221

- Oakland CA, US
Jie LI - Los Angeles CA, US
Yang LIU - Los Angeles CA, US
Jie REN - Los Angeles CA, US
Jing WEN - Culver City CA, US

A61K 9/51
A61K 38/38

The invention relates to protein nanocapsules that exhibit material properties that change in different in vivo environments. A zwitterion moiety on the surface of the nanocapsule can protect the protein from opsonization in a first environment, yet uncouples from the protein nanocapsule in a second environment (e.g. at a pH of less than 6.5). In embodiments of the invention, the uncoupled protein nanocarrier is then internalized by mammalian cells (e.g. tumor cells).

20160361425, Dec 15, 2016

Feb 23, 2015

15/120899

- Oakland CA, US
Juanjuan Du - Los Angeles CA, US
Jie Li - Los Angeles CA, US
Yang Liu - Los Angeles CA, US

A61K 47/48
A61K 38/44
A61K 38/51

Methods for modifying therapeutic agents such as therapeutic biomolecules, such as proteins for improved oral, rectal or transmucosal delivery, as well as compositions made using such methods and methods of administering such compositions to a subject, are disclosed. Specifically, the therapeutic agents are conjugated to hyperbranched polymers (HBPs), such as hyperbranched polyglycerol (HPG). When such conjugates are administered orally to a subject, the HBP protects the therapeutic agent from the acid environment of the stomach and protease attack in the gastro-intestinal tract, while facilitating the absorption of the therapeutic agent in the higher pH environment of the intestines. The methods and compositions are useful for the improved administration of a variety of therapeutic agents to a subject.