Jian Sheng Li

6911891, Jun 28, 2005

Jan 18, 2002

10/052667

Jin Qiu - Cambridge MA, US
Alexander H. Slocum - One Merrill Crossing Bow NH, US
Jeffrey H. Lang - Sudbury MA, US
Ralf Struempler - Gebenstorf, CH
Michael P. Brenner - Needham MA, US
Jian Li - Cambridge MA, US

Massachusetts Institute of Technology - Cambridge MA

H01H037/52
H01H037/54

337 53, 337 36, 337 16, 337365, 60529

A bistable structure provided by the invention is characterized as including a deflection element that has mechanically constrained end points and a compliant span between the end points that is substantially free to deflect between two stable positions when a force is applied at a point along the span. The deflection element span is provided, as-fabricated, curved in one of the two stable positions and in a mechanically unstressed condition along the length of the span. The as-fabricated curve of the deflection element span includes a curve maxima at a point along the span length that is at least about of the span length from the end points of the span. The deflection element span is constrained to substantially prohibit development of a second bending mode that is characteristic for the span as the element deflects between the two stable positions.

7850959, Dec 14, 2010

Oct 12, 2004

10/575127

Jian Li - West Roxbury MA, US
Jue-Lon Shie - Acton MA, US
Roger J. Laham - Brookline MA, US

Beth Israel Deaconess Medical Center - Boston MA

A61K 38/00
A61K 48/00
C12N 15/00
C12N 15/06
C12N 15/07

424 9321, 514 2, 514 21, 514 44 R, 435455

The present invention features methods and compositions for preventing, reducing, or treating hypoxia and pathological disorders involving abnormal angiogenesis (e. g. , conditions involving decreases or increases in blood flow, respectively). Where an increase in angiogenesis is desired, the mammal being treated for an ischemic condition is provided with Related Transcriptional Enhancer Factor-1 (RTEF-1; as a recombinant polypeptide or as an expression vector) sufficient to increase expression of VEGF, FGFR, or COX-2. This results in a concomitant increase in angiogenesis. Conversely, a mammal being treated for a hypervascular condition is administered a composition that reduces the levels of RTEF-1, thereby reducing the expression of VEGF, FGFR, or COX-2, which results in a decrease in angiogenesis. Also disclosed are screening methods that make use of RTEF-1 for the identification of novel therapeutics for the treatment, prevention, or reduction of pathological disorders involving hypoxia or abnormal angiogenesis, namely, ischemic or hypervascular conditions.

20030009898, Jan 16, 2003

Jan 18, 2002

10/052726

Alexander Slocum - Bow NH, US
Jin Qiu - Cambridge MA, US
Joachim Sihler - Somerville MA, US
Roger Cortesi - Washington DC, US
Micah Smith - Rawlings MD, US
Jian Li - Cambridge MA, US
Eun Suh - Cambridge MA, US
Shorya Awtar - Brighton MA, US

Massachusetts Institute of Technology - Cambridge MA

G01D021/00

033/706000

An instrument for enabling a precise determination of the force-displacement characteristics of a compliant structure, including both in-plane and out-of-plane structure deflection, is provided by the invention. The instrument includes a fixture that is oriented for constraining an end of the compliant structure with respect to mechanical ground as the force-displacement characteristic is determined. A mechanical probe of the instrument is disposed relative to the fixture to enable pushing of the probe against a free end of the compliant structure. A mechanical stage is provided, including a support for the probe, and being free with respect to mechanical ground to advance the probe relative to the fixture. This enables pushing of the probe against the free end of the compliant structure. A reference element is connected to the stage, and a displacement transmission element is disposed relative to the mechanical probe and the compliant reference element to transmit deflection of the compliant structure, produced by pushing of the probe, to the compliant reference element. A displacement sensor is disposed relative to the displacement transmission element to measure displacement of the transmission element, and a displacement sensor is disposed relative to the mechanical stage to measure displacement of the mechanical stage. The compliant reference element and the displacement transmission element can be configured with respect to the constraining fixture to accommodate deflection of the compliant structure along more than one axis, e.g., along either of two deflection axes.

20090014296, Jan 15, 2009

May 28, 2008

12/153979

Alexis Christian Weber - Cambridge MA, US
Alexander H. Slocum - Bow NH, US
Jeffrey Lang - Sudbury MA, US
Sami Kotilainen - Niederrohrdorf, CH
Jian Li - Fremont CA, US

ABB Research Ltd. - Zurich

H01H 57/00
H01H 1/06
H01H 11/04

200181, 200502, 29622

Micro-electromechanical (MEMS) contact configuration is disclosed, comprising a static contact with at least one contact surface and a movable contact with at least one corresponding contact surface. Particularly flat contact surfaces and correspondingly low contact resistance can be achieved, if at least one contact surface plane is formed by a crystal plane of the wafer. Furthermore a method for manufacturing such a contact configuration is proposed, wherein the contact surfaces are obtained by wet anisotropic etching of a silicon wafer, if need be preceded by appropriate masking to expose the to be edged regions only, if need be followed by coating with an electrically conductive layer, e.g., a metal layer.

20230052903, Feb 16, 2023

Sep 19, 2022

17/947937

- Shenzhen, CN
Lifeng Liu - Sudbury MA, US
Jian Li - Waltham MA, US

HUAWEI TECHNOLOGIES CO., LTD. - Shenzhen

G06N 20/20
G06K 9/62
G06N 5/02
G06F 11/34

This disclosure relates to recommendations made to users based on learned behavior patterns. User behavior data is collected and grouped according labels. The grouped user behavior data is labeled and used to train a machine learning model based on features and tasks associated with the classification. User behavior is then predicted by applying the trained machine learning model to the collected user behavior data, and a task is recommended to the user.

20200157212, May 21, 2020

Jun 8, 2018

16/614701

- New York NY, US
- Boston MA, US
Eric M. Bennett - Arlington MA, US
Huilan Gao - West Roxbury MA, US
Zong Sean Juo - Cambridge MA, US
Stefano V. Gulla - Boston MA, US
Christine Huard - Somerville MA, US
Sreekumar R. Kodangattil - Lexington MA, US
Jian Li - Chestnut Hill MA, US
Weining Lu - Boston MA, US
Xueping Fan - Boston MA, US
David J. Salant - Boston MA, US

C07K 16/28
A61P 13/12
C12N 15/85

The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.

20190019068, Jan 17, 2019

Jul 12, 2017

15/647748

- Plano TX, US
Lifeng Liu - Sudbury MA, US
Xiaotian Yin - Belmont MA, US
Jun Zhang - Cambridge MA, US
Jian Li - Austin TX, US

G06K 9/62
G06K 9/00
G05D 1/00
B60W 40/08
B60W 50/14

Methods, apparatus, and systems are provided for integrated driver expression recognition and vehicle interior environment classification to detect driver condition for safety. A method includes obtaining an image of a driver of a vehicle and an image of an interior environment of the vehicle. Using a machine learning method, the images are processed to classify a condition of the driver and of the interior environment of the vehicle. The machine learning method includes general convolutional neural network (CNN) and CNN with adaptive filters. The adaptive filters are determined based on influence of filters. The classification results are combined and compared with predetermined thresholds to determine if a decision can be made based on existing information. Additional information is requested by self-motivated learning if a decision cannot be made, and safety is determined based on the combined classification results. A warning is provided to the driver based on the safety determination.

20190012802, Jan 10, 2019

Jul 6, 2017

15/643453

- Plano TX, US
Xiaotian Yin - Belmont MA, US
Yingxuan Zhu - Cambridge MA, US
Jun Zhang - Cambridge MA, US
Jian Li - Austin TX, US

G06T 7/73

Various embodiments include systems and methods structured to provide recognition of an object in an image using a learning module trained using decomposition of the object into components in a number of training images. The training can be based on an overall objectness score of the object, an objectness score of each component of the object, a pose of the object, and a pose of each component of the object for each training image input. Additional systems and methods can be implemented in a variety of applications.