Jiahuai Han Phones & Addresses
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Phoenix, AZ
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13832 Torrey Bella Ct, San Diego, CA 92129 (858) 538-2278
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9213 Pipilo St, San Diego, CA 92129 (858) 538-4587
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Durham, NC
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Dallas, TX
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La Jolla, CA
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Maricopa, AZ
Publications
Us Patents
Assay Method
View pageUS Patent:
20020132823, Sep 19, 2002
Filed:
Jan 17, 2001
Appl. No.:
09/765206
Inventors:
Jiahuai Han - San Diego CA, US
Liguo New - San Diego CA, US
Hermann Gram - Weil, DE
Liguo New - San Diego CA, US
Hermann Gram - Weil, DE
International Classification:
A61K031/506
C 07D 4 3/14
C 07D 4 3/14
US Classification:
514/275000, 544/324000
Abstract:
An assay is provided for the identification and comparison of compounds having activity as modulators of the expression and release of TNFa, IL-1 or IL-6 in humans and animals in which modulation of the catalytic activity of PRAK (p38-regulated/activated protein kinase) is employed for identification and comparison of test compounds.
Nod1 As An Anti-Tumor Agent
View pageUS Patent:
20060194740, Aug 31, 2006
Filed:
Feb 23, 2006
Appl. No.:
11/361015
Inventors:
Richard Ulevitch - Del Mar CA, US
Jean Silva - San Diego CA, US
Jiahuai Han - San Diego CA, US
Jean Silva - San Diego CA, US
Jiahuai Han - San Diego CA, US
International Classification:
A61K 48/00
A61K 38/04
A61K 38/04
US Classification:
514019000, 514044000
Abstract:
The invention provides compositions and methods for treating tumors that involve increasing the expression of Nod1 and/or the activity of NOD1.
Nod1 As An Anti-Tumor Agent
View pageUS Patent:
20090028795, Jan 29, 2009
Filed:
Feb 27, 2006
Appl. No.:
11/884898
Inventors:
Richard J. Ulevitch - La Jolla CA, US
Jean da Silva - San Diego CA, US
Jiahuai Han - San Diego CA, US
Jean da Silva - San Diego CA, US
Jiahuai Han - San Diego CA, US
International Classification:
A61K 49/00
A61K 38/07
A61K 31/195
A61K 38/05
A61K 38/19
A61K 31/7088
A61P 35/00
A61K 31/56
C12N 5/08
G01N 33/53
A61K 38/07
A61K 31/195
A61K 38/05
A61K 38/19
A61K 31/7088
A61P 35/00
A61K 31/56
C12N 5/08
G01N 33/53
US Classification:
424 92, 514 18, 514563, 514 19, 424 851, 514182, 435371, 435 71, 514 44
Abstract:
The invention provides compositions and methods for treating tumors that involve increasing the expression of Nod1 and/or the activity of NOD1.
4-1 Bb Ligand In Inflammatory Diseases
View pageUS Patent:
20100098689, Apr 22, 2010
Filed:
Oct 16, 2007
Appl. No.:
12/311170
Inventors:
Young Jun Kang - San Diego CA, US
Jiahuai Han - San Diego CA, US
Jiahuai Han - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
A61K 39/395
A61K 31/7052
A61K 38/14
C07K 16/00
A61P 29/00
A61K 31/7052
A61K 38/14
C07K 16/00
A61P 29/00
US Classification:
4241331, 4241731, 514 44 R, 514 8, 4241581, 5303873, 530395
Abstract:
The invention provides 4-IBBL blocking agents, as well as pharmaceutical compositions and articles of manufacture comprising such blocking agents as new therapeutic interventions for sustained inflammation. Thus, the invention also provides methods for reducing sustained production of tumor necrosis factor.
Assay Systems And Methods For Measuring P38 Map Kinase, And Modulators Thereof
View pageUS Patent:
60108568, Jan 4, 2000
Filed:
Sep 3, 1997
Appl. No.:
8/922955
Inventors:
Richard J. Ulevitch - Del Mar CA
Jiahuai Han - San Diego CA
Yong Jiang - La Jolla CA
Jiahuai Han - San Diego CA
Yong Jiang - La Jolla CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C12Q 168
C12N 1563
C12N 121
C12N 510
C12N 1563
C12N 121
C12N 510
US Classification:
435 6
Abstract:
Assay systems utilizing a reporter construct based on p38 phosphorylation of myocyte enhancer factor 2 (MEF2) transcription factor are provided. The reporter construct and methods of use are provided, as well as methods of treatment of inflammatory and muscular disorders associated with MEF2-regulated gene expression.
Polypeptides Of Lipopolysaccharide Binding Protein
View pageUS Patent:
58378103, Nov 17, 1998
Filed:
Mar 15, 1994
Appl. No.:
8/215089
Inventors:
Jiahuai Han - La Jolla CA
Richard J. Ulevitch - Del Mar CA
Peter S. Tobias - San Diego CA
Richard J. Ulevitch - Del Mar CA
Peter S. Tobias - San Diego CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C07K 1447
US Classification:
530350
Abstract:
The present invention provides a first polypeptide fragment of lipopolysaccharide (LPS) binding protein (LBP) which binds to lipopolysaccharide, but prevents the LPS:LBP complex from either transferring LPS to CD14 or promoting the formation of an LPS:CD14 complex and a second polypeptide fragment of LBP which binds to CD14 receptor to inhibit binding of LPS:LBP complex to the CD14 receptor. Also included are methods of ameliorating symptoms of sepsis in a subject by administration of a LBP polypeptide of the invention, or administration of antibody to LBP polypeptide or anti-idiotype antibody.