US Patent:
20210301005, Sep 30, 2021
Inventors:
- South San Francisco CA, US
Joseph R. ARRON - South San Francisco CA, US
Daryle DEPIANTO - South San Francisco CA, US
Wendy Green HALPERN - South San Francisco CA, US
WeiYu LIN - South San Francisco CA, US
Patrick J. LUPARDUS - South San Francisco CA, US
Thirumalai Rajan RAMALINGAM - South San Francisco CA, US
Dhaya SESHASAYEE - South San Francisco CA, US
Tianhe SUN - South San Francisco CA, US
Tulika TYAGI - South San Francisco CA, US
Jia WU - South San Francisco CA, US
Yan WU - South San Francisco CA, US
Jian Ping YIN - South San Francisco CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 16/22
A61P 11/00
C07K 16/46
Abstract:
The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.