US Patent:
20040049042, Mar 11, 2004
Inventors:
Roman Davis - Durham NC, US
Alan Millar - Durham NC, US
Jeffrey Sterbenz - Durham NC, US
International Classification:
C07D221/22
Abstract:
An improved process for preparing steriods, such as 3-oxo-4-azasteroids, is described. Compounds of this type are known to be useful in the preparation of compounds having 5a-reductase inhibitor activity. The process comprises the hydrogenation of the corresponding steroid alkene in the presence of ammonium acetate, ammonium formate, and/or ammonium propionate and an appropriate catalyst.