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Jeffrey Spalazzi Phones & Addresses

  • Raleigh, NC
  • Boca Raton, FL
  • Staten Island, NY
  • New York, NY
  • Fair Lawn, NJ
  • Center Valley, PA
  • Baltimore, MD
  • 583 Sinclair Ave, Staten Island, NY 10312

Publications

Us Patents

Multi-Phased, Biodegradable And Osteointegrative Composite Scaffold For Biological Fixation Of Musculoskeletal Soft Tissue To Bone

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US Patent:
20060067969, Mar 30, 2006
Filed:
Mar 4, 2005
Appl. No.:
11/073275
Inventors:
Helen Lu - New York NY, US
Jeffrey Spalazzi - New York NY, US
Kathie Dionisio - N. Andover MA, US
International Classification:
A61F 2/02
US Classification:
424423000, 623023760
Abstract:
Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types.

Multi-Phased, Biodegradable And Osteointegrative Composite Scaffold For Biological Fixation Of Musculoskeletal Soft Tissue Of Bone

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US Patent:
20100291178, Nov 18, 2010
Filed:
Dec 22, 2009
Appl. No.:
12/655193
Inventors:
Helen H. Lu - New York NY, US
Jeffrey Spalazzi - Staten Island NY, US
Kathie Dionisio - N. Andover MA, US
Assignee:
The Trustees of Columbia University - New York NY
International Classification:
A61K 38/18
A61F 2/00
C12N 11/14
B28B 1/30
B32B 38/00
US Classification:
424423, 514 76, 435176, 264122, 264113, 156 8911
Abstract:
Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types.

Fully Synthetic Implantable Multi-Phased Scaffold

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US Patent:
20100292791, Nov 18, 2010
Filed:
Aug 12, 2009
Appl. No.:
12/583072
Inventors:
Helen H. Lu - New York NY, US
Jeffrey Spalazzi - Staten Island NY, US
Kristen L. Moffat - Oakmont PA, US
William N. Levine - New York NY, US
International Classification:
A61F 2/08
A61K 35/32
A61K 38/18
A61P 19/02
A61K 38/22
A61P 29/00
A61P 31/00
A61P 35/00
A61P 37/06
A61K 38/06
B29C 65/02
US Classification:
623 1312, 424426, 424 937, 514 76, 514 97, 514 171, 623 1314, 1563046
Abstract:
An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.

Biomimmetic Nanofiber Scaffold For Soft Tissue And Soft Tissue-To-Bone Repair, Augmentation And Replacement

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US Patent:
20110066242, Mar 17, 2011
Filed:
Aug 24, 2010
Appl. No.:
12/806912
Inventors:
Helen H. Lu - New York NY, US
Jeffrey Spalazzi - Staten Island NY, US
Kristen L. Moffat - Oakmont PA, US
William N. Levine - New York NY, US
International Classification:
A61F 2/08
A61F 2/02
US Classification:
623 1314, 623 2372
Abstract:
An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.

Non-Invasive Suture Anchor And Method

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US Patent:
20130238027, Sep 12, 2013
Filed:
Nov 16, 2011
Appl. No.:
13/880674
Inventors:
Renwen Zhang - Wayne NJ, US
Twana Davisson - Montclair NJ, US
Jeffrey Spalazzi - Fair Lawn NJ, US
International Classification:
A61B 17/04
US Classification:
606232
Abstract:
A non-invasive device for anchoring a suture includes a sheet to which a suture can be attached and an adhesive that can affix the sheet to bone. The method provides placing effective amount of an adhesive on a bone and attaching the suture to the adhesive and allowing the adhesive to set.

Biomimmetic Nanofiber Scaffold For Soft Tissue And Soft Tissue-To-Bone Repair, Augmentation And Replacement

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US Patent:
20150100121, Apr 9, 2015
Filed:
Sep 30, 2014
Appl. No.:
14/503053
Inventors:
Helen H. Lu - New York NY, US
Jeffrey Spalazzi - Staten Island NY, US
Kristen L. Moffat - Oakmont PA, US
William N. Levine - New York NY, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
A61F 2/08
A61L 27/18
US Classification:
623 1312
Abstract:
An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.

Multi-Phased, Biodegradable And Oesteointegrative Composite Scaffold For Biological Fixation Of Musculoskeletal Soft Tissue To Bone

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US Patent:
20150024063, Jan 22, 2015
Filed:
Aug 4, 2014
Appl. No.:
14/451255
Inventors:
Helen H. Lu - New York NY, US
Jeffrey Spalazzi - Staten Island NY, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
A61L 27/46
A61L 27/12
US Classification:
424602
Abstract:
Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types.

Graft Collar And Scaffold Apparatuses For Musculoskeletal Tissue Engineering And Related Methods

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US Patent:
20100047309, Feb 25, 2010
Filed:
Jun 6, 2009
Appl. No.:
12/455765
Inventors:
Helen H. Lu - New York NY, US
Jeffrey P. Spalazzi - Staten Island NY, US
Moira C. Vyner - Greenwich CT, US
Kristen L. Moffat - Oakmont PA, US
International Classification:
A61F 2/08
A61K 38/18
A61K 35/00
A61K 35/32
C08J 5/00
US Classification:
424423, 623 1314, 514 12, 424 937, 26433111
Abstract:
This application describes apparatuses and methods for musculoskeletal tissue engineering. Specifically, graft collar and scaffold apparatuses are provided for promoting fixation of musculoskeletal soft tissue to bone.This application provides for graft collars comprising biopolymer mesh and/or polymer-fiber mesh for fixing tendon to bone. In one aspect, the graft collar comprises more than one region, wherein the regions can comprise different materials configured to promote integration of and the regeneration of the interfacial region between tendon and bone.This application also provides for scaffold apparatuses and methods for fixing musculoskeletal soft tissue to bone. The scaffold apparatus is multiphasic, preferably triphasic, and each phase is configured promote growth and proliferation of a different cell and its associated tissue. In one aspect, the scaffold apparatus is triphasic, with phases comprising materials to promote growth and proliferation of fibroblasts, chondroblasts, and osteoblasts. In addition, an apparatus comprising two portions, each of said portion being the scaffold apparatus described above is provided, wherein each of said portion encases one end of a soft tissue graft. Further, a triphasic interference screw is provided.This application further provides apparatuses and methods for inducing formation of fibrocartilage comprising wrapping a graft collar with polymer-fiber mesh configured to apply compression to the graft collar. In another aspect, the polymer-fiber is applied directly to the graft to apply compression to the graft.
Jeffrey P Spalazzi from Raleigh, NC, age ~44 Get Report