Jeffrey W Godden

20050203150, Sep 15, 2005

Mar 9, 2004

10/795505

Omar Haffar - Seattle WA, US
Jeffrey Godden - Seattle WA, US
Jurgen Bajorath - Lynnwood WA, US

A61K031/4245
C07D271/12

514364000, 548132000

There is disclosed a structural genus of compounds, defined according to coordinates in three-dimensional space, that bind amino moieties on neighboring residues in a tyrosine residue 29 pocket of the matrix protein component of the HIV-1 preintegration complex (PIC), thereby preventing the PIC from binding to karyopherin α and preventing nuclear importation and integration of the HIV-1 viral genome into the host cell DNA, thereby preventing viral infection. The compounds may be utilized alone or in combinations with known inhibitors for preventing or inhibiting HIV-1 infection.

20060264475, Nov 23, 2006

May 23, 2006

11/419867

Omar HAFFAR - Seattle WA, US
Jeffrey GODDEN - Seattle WA, US
Jurgen BAJORATH - Lynnwood WA, US

CYTOKINE PHARMASCIENCES, INC. - King of Prussia PA

A61K 31/4439
A61K 31/4196
C07D 249/12
C07D 403/02

514341000, 514384000, 548263200, 546272400

There is disclosed a structural genus of compounds, defined according to coordinates in three-dimensional space, that bind amino moieties on neighboring residues in a tyrosine residue 29 pocket of the matrix protein component of the HIV-1 preintegration complex (PIC), thereby preventing the PIC from binding to karyopherin α and preventing nuclear importation and integration of the HIV-1 viral genome into the host cell DNA, thereby preventing viral infection. The compounds may be utilized alone or in combinations with known inhibitors for preventing or inhibiting HIV-1 infection.

20040197934, Oct 7, 2004

Jan 20, 2004

10/760988

Jurgen Bajorath - Lynnwood WA, US
Jeffrey Godden - Seattle WA, US

G06F019/00
G01N033/48
G01N033/50
G01N033/543

436/518000, 702/019000

A system and method for identifying a small group of compounds representative of a larger set of compounds is disclosed. The system obtains one or more descriptors, determines the median value for the values of each descriptor for a set of compounds, partitions the set of compounds into a plurality of partitions using each median value for the set of compounds, and selects compounds from each of the partitions to form a subgroup representative of the set of compounds. A system and method for virtual compound screening is also disclosed. The system recursively partitions a set of compounds based on descriptor median values where the partitions which have at least two bait compounds are recombined and repartitioned until a desired number of compounds remain in the partition.