US Patent:
20140086846, Mar 27, 2014
Inventors:
- Schenectady NY, US
Michael James Rishel - Saratoga Springs NY, US
Jeannette Christine Roberts - Burnt Hills NY, US
Assignee:
GENERAL ELECTRIC COMPANY - Schenectady NY
International Classification:
A61K 49/00
A61K 49/14
C07H 21/00
C07K 14/00
C07K 16/00
C07H 99/00
A61K 49/10
A61K 49/16
US Classification:
424 9321, 424 91, 424 932, 424 9322, 530402, 5303915, 536 187, 536 231
Abstract:
A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX):wherein R, R, R, R, R, R′, R′, R′, R′ and R′ are selected form hydrogen, a protected C-Chydroxyalkyl group, or a C-Calkyl group; R, R′are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C-Chydroxyalkyl group, a C-Calkyl group; n is an integer between 0 and 4; R, R′are selected from a hydrogen, a protecting group comprising C-Caliphatic radicals, C-Ccycloaliphatic radicals, C-Caromatic radicals, m is an integer between 1 and 10; at least one of Rand R′is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.