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Jayashree G Tikhe

from Dover, MA
Age ~57
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Also known as:
Jayashree Tikhe Lt, Girish E Tikhe, Eknath G Tikhe, Jayashree J Sundaresan, Jayashree G Tike, Jayashree Sandaresan
Related to:
Edward C Slater, 30Girish Tikhe, 60Prithvi Tikhe, 28
Connected to:
Maria Tikhomirova, 41Taras M Tikhomirov, 55Yuriy Tikhomirov, 98Mikhail S Tikhonov, 36Pavel V Tikhonov, 36Rimma M Tikhonov, 78Roman V Tikhonov, 37Tanya Tikhonov, 44Valentina L Tikhonova, 59Vera Tikhonova, 37

Jayashree Tikhe Phones & Addresses

  • Dover, MA
  • Brookline, MA
  • La Jolla, CA
  • 4504 Shorepointe Ct, San Diego, CA 92130
  • Brighton, MA

Work

Company: Celgene Position: Associate scientist

Industries

Pharmaceuticals

Resumes

Resumes

Jayashree Tikhe Photo 1

Associate Scientist

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Location:
11 Turtle Ln, Dover, MA 02030
Industry:
Pharmaceuticals
Work:
Celgene
Associate Scientist

Publications

Us Patents

Tricyclic Inhibitors Of Poly(Adp-Ribose) Polymerases

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US Patent:
6548494, Apr 15, 2003
Filed:
Aug 31, 2000
Appl. No.:
09/653184
Inventors:
Stephen Evan Webber - San Diego CA
Donald James Skalitzky - San Diego CA
Jayashree Girish Tikhe - San Diego CA
Robert Arnold Kumpf - Encinitas CA
Joseph Timothy Marakovits - Encinitas CA
Brian Walter Eastman - San Diego CA
Assignee:
Agouron Pharmaceuticals, Inc. - San Diego CA
International Classification:
C07D48706
US Classification:
514220, 540496, 540499
Abstract:
Compounds of the formula shown below are poly(ADP-ribosyl)transferase inhibitors: Such compounds are useful as therapeutics in treating cancers and in ameliorating the effects of stroke, head trauma, and neurodegenerative disease.

Antipicornaviral Compounds, Their Preparation And Use

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US Patent:
6906198, Jun 14, 2005
Filed:
Jan 5, 1999
Appl. No.:
09/647712
Inventors:
Peter Scott Dragovich - San Diego CA, US
Stephen Evan Webber - San Diego CA, US
Thomas Jay Prins - Cardiff CA, US
Ru Zhou - Carlsbad CA, US
Joseph Timothy Marakovits - Encinitas CA, US
Jayashree Girish Tikhe - San Diego CA, US
Assignee:
Agouron Pharmaceuticals, Inc. - San Diego CA
International Classification:
C07D207/00
US Classification:
548416, 560128, 548534, 562553
Abstract:
Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.

Tricyclic Inhibitors Of Poly(Adp-Ribose) Polymerases

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US Patent:
6977298, Dec 20, 2005
Filed:
Dec 3, 2004
Appl. No.:
11/004261
Inventors:
Stephen Evan Webber - San Diego CA, US
Jayashree Tikhe - San Diego CA, US
Lars Henrik Thoresen - College Station TX, US
Assignee:
Agouron Pharmacetucals, Inc. - La Jolla CA
Cancer Research Campaign Technology Limited - London
International Classification:
C07D487/06
C07D471/06
C07D481/00
US Classification:
540520, 546 84
Abstract:
Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e. g. , in combination with cytotoxic agents and/or radiation.

Tricyclic Inhibitors Of Poly(Adp-Ribose) Polymerases

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US Patent:
7429578, Sep 30, 2008
Filed:
Sep 6, 2005
Appl. No.:
11/221245
Inventors:
Stephen Evan Webber - San Diego CA, US
Jayashree Tikhe - San Diego CA, US
Lars Henrik Thoresen - College Station TX, US
Assignee:
Agouron Pharmaceuticals, Inc. - San Diego CA
Cancer Research Campaign Technology Limited - London
International Classification:
A61P 35/00
A61P 43/00
US Classification:
51421204, 514220, 514411
Abstract:
Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease.

Carbonylamino Pyrrolopyrazoles, Potent Kinase Inhibitors

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US Patent:
7884117, Feb 8, 2011
Filed:
Dec 12, 2006
Appl. No.:
12/158241
Inventors:
Junhun Zhang - San Diego CA, US
Anle Yang - San Diego CA, US
Susan Elizabeth Kephart - San Diego CA, US
Liming Dong - Shanghai, CN
Chuangxing Guo - San Diego CA, US
Yufeng Hong - San Diego CA, US
Mary Catherine Johnson - San Diego CA, US
Indrawan James McAlpine - San Diego CA, US
Jayashree Tikhe - San Diego CA, US
Haitao Li - Rockville MD, US
Assignee:
Pfizer Inc. - New York NY
International Classification:
A61K 31/422
A61K 31/4162
C07D 261/06
C07D 231/54
US Classification:
514378, 514406, 548248, 5483605
Abstract:
Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.

Aminotriazolopyridines, Compositions Thereof, And Methods Of Treatment Therewith

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US Patent:
8299056, Oct 30, 2012
Filed:
Sep 8, 2009
Appl. No.:
12/555018
Inventors:
Sogole Bahmanyar - San Diego CA, US
R.J. Bates - Oceanside CA, US
Kate Blease - San Diego CA, US
Andrew Calabrese - San Diego CA, US
Thomas Daniel - San Diego CA, US
Mercedes Delgado - San Diego CA, US
Jan Elsner - San Diego CA, US
Paul Erdman - San Diego CA, US
Bruce Fahr - San Diego CA, US
Gregory Ferguson - San Diego CA, US
Branden Lee - Encinitas CA, US
Lisa Nadolny - San Diego CA, US
Garrick Packard - San Diego CA, US
Patrick Papa - Carlsbad CA, US
Jennifer Riggs - Cardiff CA, US
Patricia Rohane - Florham Park NJ, US
Sabita Sankar - San Diego CA, US
John Sapienza - Chula Vista CA, US
Yoshitaka Satoh - Poway CA, US
Victor Sloan - Flemington NJ, US
Randall Stevens - Plainfield NJ, US
Lida Tehrani - San Diego CA, US
Jayashree Tikhe - San Diego CA, US
Eduardo Torres - San Diego CA, US
Andrew Wallace - San Diego CA, US
Brandon Wade Whitefield - San Diego CA, US
Jingjing Zhao - San Diego CA, US
Assignee:
Signal Pharmaceuticals, LLC - San Diego CA
International Classification:
A61K 31/437
A61K 31/5377
A61K 31/497
A61K 31/55
C07D 471/02
US Classification:
51421021, 514303, 5142332, 51425304, 51421707, 546119, 544125, 544362, 540597
Abstract:
Provided herein are Heteroaryl Compounds of formula (I):.

Tricyclic Inhibitors Of Poly(Adp-Ribose) Polymerases

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US Patent:
20030078254, Apr 24, 2003
Filed:
Oct 2, 2002
Appl. No.:
10/264018
Inventors:
Stephen Webber - San Diego CA, US
Jayashree Tikhe - San Diego CA, US
Lars Thoresen - College Station TX, US
International Classification:
A61K031/55
A61K031/4745
C07D491/04
C07D471/04
US Classification:
514/212060, 514/292000, 540/520000, 546/084000
Abstract:
Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.

3,5 Disubstituted Indazole Compounds With Nitrogen-Bearing 5-Membered Heterocycles, Pharmaceutical Compositions, And Methods For Mediating Or Inhibiting Cell Proliferation

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US Patent:
20050090529, Apr 28, 2005
Filed:
Aug 2, 2004
Appl. No.:
10/910217
Inventors:
Indrawan McAlpine - San Diego CA, US
Judith Deal - Wildomar CA, US
Mary Johnson - San Diego CA, US
Susan Kephart - San Diego CA, US
Julie Park - Cambridge MA, US
William Romines - San Diego CA, US
Jayashree Tikhe - San Diego CA, US
International Classification:
A61K031/4439
C07D043/14
US Classification:
514338000, 546268100
Abstract:
3,5 disubstituted indazole compounds with substituted nitrogen bearing 5-membered heterocycles in the 3-position that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
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Jayashree G Tikhe from Dover, MA, age ~57 Get Report