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Jasodhara Pt Ray

from San Diego, CA
Age ~79
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Also known as:
Jasodhara J Ray, Ray J Jasodhara
Phone and address:
4184 Corte De La Siena, San Diego, CA 92130
Connected to:
Adelia R Ray, 66Adina Ray, 44Aimee L Ray, 44Alaina M Ray, 44Alejandro A Ray, 58Alycia M Ray, 34Alysha B Ray, 35Alyson W Ray, 69Amartya K Ray, 44Amiya R Ray, 41

Jasodhara Ray Phones & Addresses

  • 4184 Corte De La Siena, San Diego, CA 92130
  • Del Mar, CA

Work

Position: Professional/Technical

Education

Degree: High school graduate or higher

Resumes

Resumes

Jasodhara Ray Photo 1

Staff Scientist

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Location:
San Diego, CA
Industry:
Research
Work:
Salk Institute
staff scientist
Education:
Presidency College 1962 - 1965
B.Sc., Chemistry
Jasodhara Ray Photo 2

Jasodhara Ray

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Location:
San Diego, CA

Publications

Us Patents

Stimulation Of Cell Proliferation By Glycosylated Cystatin C

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US Patent:
6436389, Aug 20, 2002
Filed:
Dec 13, 1999
Appl. No.:
09/459958
Inventors:
Fred Harrison Gage - La Jolla CA
Philippe J. Taupin - La Jolla CA
Jasodhara Ray - San Diego CA
Assignee:
The Salk Institute for Biological Studies - La Jolla CA
International Classification:
A61K 3800
US Classification:
424 851, 4241981, 435 4, 435325, 435375, 435377, 514 2, 514 12, 530350, 530399
Abstract:
The present invention is based on the discovery and isolation of a co-factor for trophic factors. It has been discovered that trophic factors require a co-factor to stimulate and/or potentiate the trophic factor activity and/or specificity. This was clearly identified in low density cells where trophic factors are unable, or at best, at minimal levels, able to proliferate undifferentiated cells without a co-factor. In a particular embodiment of the present invention, there is provided a composition comprising glycosylated cystatin C, (CCg), an FGF co-factor that stimulates proliferation of neural and fibroblast associated undifferentiated cells. The N-glycosylation of cystatin C is required for its activity. Moreover, CCg acts in cooperation with basic fibroblast growth factor (FGF-2) to induce neural progenitor cell proliferation.

Method For Assaying For Early Gene Expression In Neuroblasts

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US Patent:
6599695, Jul 29, 2003
Filed:
Jul 24, 2001
Appl. No.:
09/915229
Inventors:
Fred H. Gage - La Jolla CA, 92037
Jasodhara Ray - San Diego CA, 92130
International Classification:
C12Q 102
US Classification:
435 4, 435 6, 435 71, 435 72, 435 721, 435 29
Abstract:
A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.

Pharmaceutical Composition Comprising Ribavirin And Growth Factors And Methods Of Use

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US Patent:
6680292, Jan 20, 2004
Filed:
Sep 24, 2001
Appl. No.:
09/856100
Inventors:
Roger C. Guillemin - La Jolla CA
Fred Harrison Gage - La Jolla CA
Jasodhara Ray - San Diego CA
Assignee:
The Salk Institute for Biological Studies - La Jolla CA
International Classification:
A61K 3170
US Classification:
514 2, 514 27, 514 43, 514 45, 514 46, 530397, 530399
Abstract:
The present invention is directed to compositions comprising 1-(-D-ribofuranosyl)-1H-1,2,4-triazole compounds and either endogenous or exogenous neurotrophic factors. Methods of using such compounds and compositions are also provided. In one aspect, the invention provides methods of using invention compositions and compounds to enhance neurite outgrowth, neuronal survival and neuronal proliferation in mammalian cells. In a preferred embodiment, a 1-(-D-ribofuranosyl)1H-1,2,4-triazole compound is infused directly to a desired situs. In a more preferred embodiment the 1-(-D-ribofuranosyl)-1,2,4-triazole compound is administered orally. In another aspect, the invention provides methods of treating a neurological disease in a mammal subject. In a further aspect, the invention provides methods of treating neuronal trauma in a mammal subject.

Human Cns Cell Lines And Methods Of Use Therefor

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US Patent:
6713247, Mar 30, 2004
Filed:
Sep 3, 1996
Appl. No.:
08/711628
Inventors:
Fred H. Gage - La Jolla CA
Jasodhara Ray - San Diego CA
Assignee:
Signal Pharmaceuticials, Inc. - San Diego CA
International Classification:
C12N 508
US Classification:
435 4, 435 691, 435325, 435366, 435368, 435455, 435456
Abstract:
Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.

Method For Production Of Neuroblasts

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US Patent:
7732201, Jun 8, 2010
Filed:
Nov 3, 2006
Appl. No.:
11/592504
Inventors:
Fred H. Gage - La Jolla CA, US
Jasodhara Ray - San Diego CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12N 5/06
C12N 5/08
US Classification:
435368, 435375, 435376, 435377, 435384, 435387
Abstract:
A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.

Co-Factors For Trophic Factors, And Methods Of Use, Thereof

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US Patent:
20030022261, Jan 30, 2003
Filed:
Aug 20, 2002
Appl. No.:
10/225322
Inventors:
Fred Gage - La Jolla CA, US
Philippe Taupin - La Jolla CA, US
Jasodhara Ray - San Diego CA, US
International Classification:
G01N033/574
A61K038/16
C07K009/00
A61K038/14
US Classification:
435/007230, 514/008000, 530/322000
Abstract:
The present invention is based on the discovery and isolation of a co-factor for trophic factors. It has been discovered that trophic factors require a co-factor to stimulate and/or potentiate the trophic factor activity and/or specificity. This was clearly identified in low density cells where trophic factors are unable, or at best, at minimal levels, able to proliferate undifferentiated cells without a co-factor. In a particular embodiment of the present invention, there is provided a composition comprising glycosylated cystatin C (CCg), an FGF co-factor that stimulates proliferation of neural and fibroblast associated undifferentiated cells. The N-glycosylation of cystatin C is required for its activity. Moreover, CCg acts in cooperation with basic fibroblast growth factor (FGF-2) to induce neural progenitor cell proliferation.

Method For Production Of Neuroblasts

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US Patent:
20040048373, Mar 11, 2004
Filed:
Jul 18, 2003
Appl. No.:
10/622206
Inventors:
Fred Gage - La Jolla CA, US
Jasodhara Ray - San Diego CA, US
International Classification:
C12N005/08
US Classification:
435/368000
Abstract:
A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.

Human Cns Cell Lines And Methods Of Use Therefor

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US Patent:
20050037495, Feb 17, 2005
Filed:
Mar 29, 2004
Appl. No.:
10/813203
Inventors:
Dinah Sah - San Diego CA, US
Fred Gage - La Jolla CA, US
Jasodhara Ray - San Diego CA, US
International Classification:
C12N005/08
C12N015/85
US Classification:
435455000, 435368000
Abstract:
Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.
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Jasodhara Pt Ray from San Diego, CA, age ~79 Get Report