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Janine M Orban

from Fort Wayne, IN
Age ~51

Janine Orban Phones & Addresses

  • 2211 Braemar Dr, Fort Wayne, IN 46814 (260) 616-0258
  • 222 Lakeland Dr, Warsaw, IN 46580
  • Gibsonia, PA
  • 1411 Grandview Ave, Pittsburgh, PA 15211 (412) 488-7773
  • Allison Park, PA
  • Decatur, GA

Publications

Us Patents

Porous Delivery Scaffold And Method

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US Patent:
7201917, Apr 10, 2007
Filed:
Jul 15, 2002
Appl. No.:
10/195633
Inventors:
Prasanna Malaviya - Ft. Wayne IN,
Herbert E. Schwartz - Ft. Wayne IN,
Pamela L. Plouhar - South Bend IN,
Janine M. Orban - Warsaw IN,
Assignee:
Depuy Products, Inc. - Warsaw IN
International Classification:
A61K 45/00
C12N 5/02
US Classification:
424423, 426384, 435325
Abstract:
A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. The scaffold may further comprise biological agents that promote tissue repair and healing. Porous implantable scaffolds fabricated by such a method are also disclosed.

Hybrid Biologic-Synthetic Bioabsorbable Scaffolds

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US Patent:
7569233, Aug 4, 2009
Filed:
Apr 20, 2005
Appl. No.:
11/110169
Inventors:
Prasanna Malaviya - Fort Wayne IN,
Janine M. Orban - Warsaw IN,
Philip J. Jenks - Warsaw IN,
Terrence D. Whalen - Leesburg IN,
Assignee:
DePuy Products, Inc. - Warsaw IN
International Classification:
B27N 3/00
A61F 2/00
A61F 2/02
C12N 9/10
US Classification:
424422, 424423, 264109
Abstract:
A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion.

Implant Device For Cartilage Regeneration In Load Bearing Articulation Regions

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US Patent:
7666230, Feb 23, 2010
Filed:
Dec 8, 2003
Appl. No.:
10/730423
Inventors:
Janine M. Orban - Warsaw IN,
Herbert E. Schwartz - Fort Wayne IN,
Nathaniel W. Grobe - Warsaw IN,
Assignee:
DePuy Products, Inc. - Warsaw IN
International Classification:
A61F 2/30
US Classification:
623 2358, 623 2375
Abstract:
An implant device for cartilage regeneration in loading-bearing regions uses the osteochondral defect model. The implant is formed of resorbable polymeric materials. The implant is designed such that load is transmitted from the articulating surface of the bone platform through the implant to the entire area of subchondral bone of the bone platform. Application of load in this manner results in reduced subchondral bone resorption, leading to joint stabilization and maintenance of normal joint biomechanics. The implant allows for the incorporation therein of a resorbable scaffold or matrix material. The present implant solves the current inability to regenerate cartilage in load-bearing articulating surfaces using engineered scaffold devices.

Biological Component Comprising Artificial Membrane

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US Patent:
7713544, May 11, 2010
Filed:
Jul 30, 2001
Appl. No.:
10/343408
Inventors:
Elliot L. Chaikof - Atlanta GA,
June Feng - Duluth GA,
Janine M. Orban - Warsaw IN,
Hongbo Liu - Hillsborough NJ,
Xue Long Sun - Atlanta GA,
Keith M. Faucher - Athens GA,
Assignee:
Emory University - Atlanta GA
International Classification:
A61L 27/00
A61F 13/00
A61K 9/127
US Classification:
424450, 623 149, 623 242, 623 1111, 427 228, 427 23, 427 231, 424422, 424423
Abstract:
A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e. g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of cells, such as islet cells, for transplantation. The surface may present exposed bioactive molecules or moieties for binding to target molecules in vivo, for modulating host response when implanted into a patient (e. g. the surface may be antithrombogenic or antiinflammatory) and the surface may have pores of selected sizes to facilitate transport of substances therethrough. An optional hydrophilic cushion or spacer between the substrate and the membrane-mimetic surface allows transmembrane proteins to extend from the surface through the hydrophilic cushion, mimicking the structure of naturally-occurring cells. An alkylated layer directly beneath the membrane-mimetic surface facilates bonding of the surface to the remainder of the biological component. Alkyl chains may extend entirely through the hydrophilic cushion when present.

Chemical Treatment For Removing Cellular And Nuclear Material From Naturally Occurring Extracellular Matrix-Based Biomaterials

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US Patent:
7763459, Jul 27, 2010
Filed:
Sep 30, 2004
Appl. No.:
10/954971
Inventors:
Rangamani Padmini - New York NY,
Janine Orban - Warsaw IN,
Prasanna Malaviya - Fort Wayne IN,
Assignee:
DePuy Spine, Inc. - Raynham MA
International Classification:
C12P 1/00
C12P 5/02
US Classification:
435325, 435 41, 424 937, 424423
Abstract:
A method is provided for sequential decellularization of an isolated tissue using solubilizing solutions comprising at least one oxidizing agent that removes all cellular and nuclear materials from the tissue while substantially maintaining the biological and, mechanical properties, and the biochemical properties of the resulting extracellular matrix.

Antithrombogenic Membrane Mimetic Compositions And Methods

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US Patent:
20040073295, Apr 15, 2004
Filed:
Apr 15, 2003
Appl. No.:
10/257805
Inventors:
Elliot Chaikof - Atlanta GA,
June Feng - Duluth GA,
Janine Orban - Pittsburgh PA,
Hongbo Liu - Willimantic CT,
International Classification:
A61F002/06
US Classification:
623/001460
Abstract:
The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other implanted materials. The materials comprising bound thrombomodulin or a functionally equivalent derivative protein, provide for fewer undesirable side effects including inflammation, thromboses and neointimal hyperplasia.

Hybrid Biologic-Synthetic Bioabsorbable Scaffolds

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US Patent:
20050249772, Nov 10, 2005
Filed:
Apr 20, 2005
Appl. No.:
11/110532
Inventors:
Prasanna Malaviya - Fort Wayne IN,
Janine Orban - Warsaw IN,
International Classification:
A61F002/00
B27N003/00
US Classification:
424423000, 264109000
Abstract:
A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion.

Coated Biomedical Device And Associated Method

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US Patent:
20060068224, Mar 30, 2006
Filed:
Sep 30, 2004
Appl. No.:
10/957292
Inventors:
George Grobe - Fort Wayne IN,
Janine Orban - Warsaw IN,
Mark Heldreth - Mentone IN,
Richard Tarr - Winona Lake IN,
Don Paquin - San Jose CA,
Jonathon Spanyer - West Chester OH,
International Classification:
A61L 33/00
B32B 19/00
US Classification:
428696000, 427002100
Abstract:
The present invention provides a halogen coated biomedical device and a method for producing the device. The method generally involves generating a plasma that affects the release of a halogen species from a source. The halogen reacts with the surface of the biomedical device to form a halogen coating.
Janine M Orban from Fort Wayne, IN, age ~51 Get Report