US Patent:
20070225242, Sep 27, 2007
Inventors:
Janine Erler - San Francisco CA, US
Amato Giaccia - Stanford CA, US
International Classification:
A61K 48/00
G01N 33/574
A61K 39/395
US Classification:
514044000, 424146100, 435007230
Abstract:
Methods, compositions and kits are provided for effectively treating and preventing cancer metastasis in vivo and for increasing survival of subjects burdened with metastatic tumors by targeting a lysyl oxidase or its modulator, especially human lysyl oxidase. Also provided are methods for identifying lysyl oxidase inhibitors and the use of such inhibitors to prevent and treat tumors, particularly metastatic tumors, alone and in combination with chemotherapeutic agents. Further disclosed is the use of lysyl oxidase levels for measuring metastatic potential and survival.