Inventors:
Robert A. Lazarus - Millbrae CA
Mark S. Dennis - San Carlos CA
Jana Seymour Ulmer - San Rafael CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 1481
A61K 3855
Abstract:
A potent serine protease inhibitor capable of inhibiting Factor Xa, Factor XIIa, plasma kallikrein, and human leukocyte elastase is provided. The inhibitor is provided in a pharmaceutical composition for treatment of diseases where inhibition of Factor Xa, Factor XIIa, plasma kallikrein, or HLE is indicated.