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James E Trosko

from Okemos, MI
Age ~86
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Also known as:
James Edward Trosko, Trosko Trosko, Philip Trosko
Phone and address:
1630 Sylvan Glen Rd, Okemos, MI 48864
(517) 349-0449
Related to:
Dorothy M TroskoBeverly K Trosko, 85Philip R Trosko, 58
Connected to:
John M Trosko, 84Paul J Troskosky, 79Gregg A Trosky, 65Rachel L Trosky, 31Susan E Trosky, 85Benjamin W Trosper, 34Bill J Trosper, 78Brooke Trosper, 52Christine S Trosper, 38Derek J Trosper, 34

James Trosko Phones & Addresses

  • 1630 Sylvan Glen Rd, Okemos, MI 48864 (517) 349-0449
  • Norton Shores, MI
  • Mason, MI
  • 1630 Sylvan Glen Rd, Okemos, MI 48864

Work

Company: Michigan state university Position: Professor

Industries

Higher Education

Resumes

Resumes

James Trosko Photo 1

Professor At Michigan State University

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Position:
Professor at Michigan State University
Location:
Lansing, Michigan Area
Industry:
Higher Education
Work:
Michigan State University
Professor

Publications

Us Patents

Non-Fiber Extract Of Psyllium With Anti-Tumorigenic Effects And Method For Identifying The Same

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US Patent:
7195789, Mar 27, 2007
Filed:
Feb 27, 2003
Appl. No.:
10/375401
Inventors:
Yasushi Nakamura - Kyoto, JP
Brad L. Upham - East Lansing MI, US
James E. Trosko - Okemos MI, US
Assignee:
Board of Trustees of Michigan State University - East Lansing MI
International Classification:
A61K 36/00
US Classification:
424738
Abstract:
A composition comprising a non-fiber organic extract of psyllium which is anti-tumorigenic is described. The composition both restores gap junctional intercellular communication (GJIC) and inhibits anchorage independent growth of mammalian cells which have been transformed with the ras oncogene. The composition is a useful chemotherapy and chemopreventative agent. The composition was identified using a novel method for determining the anti-tumorigenic potential of a compound or composition.

Hydroxyl Radical Detection

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US Patent:
7939340, May 10, 2011
Filed:
Jun 28, 2006
Appl. No.:
11/478959
Inventors:
Andrea Yuki Satoh - Holt MI, US
Susan J. Masten - Ancaseter, CA
James Trosko - Okemos MI, US
Assignee:
Board Of Trustees Of Michigan State University - East Lansing MI
International Classification:
G01N 21/77
US Classification:
436169, 436131, 436164, 436514, 436518, 435 71, 435 74, 435 17, 422 56, 422 57, 422 8205, 422 61
Abstract:
The invention relates to compositions, kits and methods used in hydroxyl radical detection. In some embodiments, the invention relates to compositions comprising a dye preferably methylene blue immobilized on a substrate. In additional embodiments, the invention relates methods of correlating color changes of a dye to the presence or absence of hydroxyl radicals. In some embodiments, the invention relates to a methylene blue dye containing test strip and its use in a method for detecting the presence of hydroxyl radicals.

Human Pancreatic Pluripotential Stem Cell Line

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US Patent:
20030003088, Jan 2, 2003
Filed:
Apr 30, 2002
Appl. No.:
10/135801
Inventors:
Ming Tsao - Toronto, CA
James Trosko - Okemos MI, US
Burra Madhukar - Okemos MI, US
Lawrence Olson - East Lansing MI, US
Loretta VanCamp - East Lansing MI, US
Assignee:
Board of Trustees operating Michigan State University - East Lansing MI
International Classification:
A61K048/00
C12N005/08
C12N015/86
US Classification:
424/093210, 435/366000, 435/456000
Abstract:
A human pancreatic ductal epithelial cell line immortalized with the human papilloma virus E6 and E7 genes which has stem cell-like characteristics and which can be induced to differentiate into ductal-like cells and beta-like cells that produce insulin. The immortal cells or derivative thereof are useful for treating insulin-dependent diabetes and in assays for determining the ability of a chemical to induce pancreatic stem cell differentiation or malignancy.

Method For Restoration Of Gap Junctional Intercellular Connection

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US Patent:
20060228433, Oct 12, 2006
Filed:
Apr 27, 2006
Appl. No.:
11/412743
Inventors:
Yasushi Nakamura - Kyoto, JP
Brad Upham - East Lansing MI, US
James Trosko - Okemos MI, US
Assignee:
Board of Trustees of Michigan State University - East Lansing MI
International Classification:
A61K 36/68
A61K 31/56
US Classification:
424738000, 514169000
Abstract:
A method for restoring gap junctional intercellular communication (GJIC) in the cells of a mammal, including humans. The method includes administering to mammals who have been determined to have a mutation in the ras gene a phytosterol to restore GJIC. The phytosterol can be β-sitosterol, stigmasterol, or mixtures of these phytosterols. Administering the phytosterol compound both restores gap junctional intercellular communication (GJIC) and inhibits anchorage independent growth of mammalian cells which have a mutation in the ras gene.

Expression Of Estrogen Receptors In Type I And Type Ii Human Breast Epithelial Cells

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US Patent:
61401196, Oct 31, 2000
Filed:
Jan 29, 1997
Appl. No.:
8/790659
Inventors:
Chia-Cheng Chang - Okemos MI
James Trosko - Okemos MI
Assignee:
Michigan State University - East Lansing MI
International Classification:
C12N 500
C12N 502
C12N 508
US Classification:
435371
Abstract:
A method is described for culturing morphologically and antigenically distinguishable types of normal human breast epithelial cells (HBEC) derived from reduction mammoplasty. Type I HBEC showed luminal and stem cell characteristics i. e. the ability to form budding/ductal structures when cultured on MATRIGEL and expressed a variant ER (. about. 48 Kd) which has a deletion in the DNA binding domain (exon 2). In contrast, Type II HBEC with basal epithelial phenotype are ER-negative when cultured on MATRIGEL. Simian virus 40 (SV40) transformed Type I and Type II HBEC lines also expressed the variant ER. Tumors formed in athymic nude mice by in vitro transformed tumorigenic Type I cell lines, however, expressed a high level of wild type ER which was undetectable in these cells grown in vitro before and after tumor formation. Thus, there appears to be a differentional ER mRNA splicing between the in vitro and in vivo milieu.

Human Breast Epithelial Cell Type With Stem Cell And Luminal Epithelial Cell Characteristics

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US Patent:
56503172, Jul 22, 1997
Filed:
Sep 16, 1994
Appl. No.:
8/308118
Inventors:
Chia-Cheng Chang - Okemos MI
James E. Trosko - Okemos MI
Assignee:
Michigan State University - East Lansing MI
International Classification:
C12N 500
US Classification:
435371
Abstract:
Described is a substantially purified human breast epithelial cell (Type I HBEC) displaying the following characteristics: variable cell shape; smooth cell colony boundary; deficiency in gap junctional intercellular communication; positive expression of epithelial membrane antigen and keratin 18; negative expression of keratin 14,. alpha. 6 integrin and gap junction genes for connexins (Cx26, Cx32 and Cx43); growth promotion by fetal bovine serum; induction by cholera toxin to differentiate into Type II HBEC (prior art); and acquisition of anchorage independent growth by Semian virus 40 transfection. Also described is a method of obtaining the above-identified epithelial cells comprising the steps of: a) development of a mixture of human breast epithelial cells from reduction mammoplasty tissues using the MSU-1 medium; b) eliminating stromal fibroblasts by a trypsin (0. 002%) and ethylenediamine tetraacetic acid (0. 02%) solution; c) separating Type I HBEC from Type II HBEC which attach on culture dishes earlier by collecting Type I HBEC that remain in suspension after trypsinization and prolonged incubation; d) the continuing culture of these cells in MSU-1 medium supplemented with fetal bovine serum, which inhibits the growth of Type II HBEC while promoting the growth of Type I HBEC, gives rise to Type I HBEC.

Human Breast Epithelial Cell Type With Stem Cell And Luminal Epithelial Cell Characteristics

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US Patent:
58145117, Sep 29, 1998
Filed:
Nov 16, 1995
Appl. No.:
8/558786
Inventors:
Chia-Cheng Chang - Okemos MI
James E. Trosko - Okemos MI
Assignee:
Michigan State University - East Lansing MI
International Classification:
C12N 500
US Classification:
4352402
Abstract:
Described is a substantially purified human breast epithelial cell (Type I HBEC) displaying the following characteristics: variable cell shape; smooth cell colony boundary; deficiency in gap junctional intercellular communication; positive expression of epithelial membrane antigen and keratin 18; negative expression of keratin 14,. alpha. 6 integrin and gap junction genes for connexins (Cx26, Cx32 and Cx43); growth promotion by fetal bovine serum; induction by cholera toxin to differentiate into Type II HBEC (prior art); and acquisition anchorage independent growth by Semian virus 40 transfection. Also described is a method of obtaining the above-identified epithelial cells comprising the steps of: a) development of a mixture of human breast epithelial cells from reduction mammoplasty tissues using the MSU-1 medium; b) eliminating stromal fibroblasts by a trypsin (0. 002%) and ethylenediamine tetraacetic acid (0. 02%) solution; c) separating Type I HBEC from Type II HBEC which attach on culture dishes earlier by collecting Type I HBEC that remain in suspension after trypsinization and prolonged incubation; d) the continuing culture of these cells in MSU-1 medium supplemented with fetal bovine serum, which inhibits the growth of Type II HBEC while promoting the growth of Type I HBEC, gives rise to Type I HBEC.

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The Role of Chemical Inhibition of Gap-Junctional Intercellular Communication in Toxicology

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Author

James E. Trosko

Binding

Paperback

Publisher

PN

ISBN #

5

The Role of Gap-Junctional Communication in Chemical Toxicology

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Author

James E. Trosko

Binding

Paperback

Publisher

PN

ISBN #

4

Oxidative Stress, Signal Transductions, Cell-Cell Communication

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Author

James E. Trosko

Binding

Paperback

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PN

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3

Oxidative Stress, Signal Transduction, Cell-Cell Communication

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Author

James E. Trosko

Binding

Paperback

Publisher

PN

ISBN #

2

DURIP - Upgrade of the Meridian ACAS-470 for Toxicological Research

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Author

James E. Trosko

Binding

Paperback

Publisher

PN

ISBN #

1

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James E Trosko from Okemos, MI, age ~86 Get Report