James R Shroff

43025919, Nov 24, 1981

Sep 2, 1980

6/182885

James R. Shroff - Riverside CT
Bernard Loev - Scarsdale NY

USV Pharmaceutical Corporation - Tuckahoe NY

C07D40104
C07D40114
C07D21182

546257

Iminobenzyl dihydropyridines of the formula ##STR1## wherein, each R is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, sulfonamido, halogen, alkoxy, alkenyloxy, alkynyloxy, cyano, hydroxy, acyloxy, nitro, amino, alkylmercapto, alkylamino, alkanoylamino, carbalkoxyamino, carboxy, methanesulfonyl, carbalkoxy or trifluoromethyl; each R. sub. 4 is lower alkoxy; each R. sub. 2 is lower alkyl; and R. sub. 3 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic or ##STR2## wherein R is as previously defined; have anti-hypertensive activity.

40227839, May 10, 1977

Dec 18, 1975

5/641966

James R. Shroff - Riverside CT
Peter P. Cervoni - New Rochelle NY

USV Pharmaceutical Corporation - Tuckahoe NY

C07D40104
C07D40106

260268H

Compounds of the structure ##STR1## wherein R is lower alkyl or ##STR2## WHEREIN R. sub. 1 and R. sub. 2 are hydrogen, lower alkyl, lower alkoxy, hydroxy, amino, nitro, halogen and trifluoromethyl and may be the same or different, and m and n are integers from 0 to 1 have potent hypotensive activity.

42645050, Apr 28, 1981

Dec 26, 1979

6/107020

James R. Shroff - Riverside CT
Rohit Desai - Yonkers NY

USV Pharmaceutical Corporation - Tuckahoe NY

C07C14942
C07D29500

2603265S

Compounds of the formula ##STR1## wherein R is lower alkyl, phenyl, lower alkenyl, cycloalkyl and substituted phenyl; R. sub. 1 is hydrogen, lower alkyl, lower alkenyl, lower alkoxy, amino, lower alkylamino, hydroxy, halo, nitro, mercapto, trifluoromethyl, lower alkylmercapto, and trifluoromethylmercapto; R. sub. 2, R. sub. 3 are lower alkyl or taken together with N form a cyclic amine; X is O or S, and n is an integer from 2 to 4 are useful in treatment of arrhythmia.

45005281, Feb 19, 1985

Mar 3, 1983

6/471593

Bernard Loev - Scarsdale NY
Howard Jones - Ossining NY
James R. Shroff - Riverside CT

USV Pharmaceutical Corporation - Tarrytown NY

A61K 31535
C07D41306

514228

The compounds of the formula: ##STR1## wherein each of the substituents is as defined herein are useful anti-hypertensive agents.

43293450, May 11, 1982

Apr 28, 1980

6/144469

James R. Shroff - Riverside CT
Rohit Desai - Yonkers NY

USV Pharmaceutical Corporation - Tuckahoe NY

C07D21128
A61K 3144

424251

Compounds of the formula ##STR1## wherein R is hydrogen, alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, hydroxy, nitro, trifluoromethyl, mercapto, or alkylmercapto, and may be the same or different, n is an integer from 2 to 4, and R. sub. 1 and R. sub. 2 are hydrogen or alkyl and may be the same or different, or R. sub. 1 and R. sub. 2 taken together with the nitrogen to which they are attached may be pyrrolidino, piperidino or morpholino and their pharmaceutically acceptable, non-toxic acid addition salts have anti-arrhythmic activity.

43049141, Dec 8, 1981

Jul 7, 1980

6/166424

James R. Shroff - Riverside CT
Bernard Loev - Scarsdale NY

USV Pharmaceutical Corporation - Tuckahoe NY

C07D47104

546123

Compounds of the formula ##STR1## wherein each of R, R. sub. 1 and R. sub. 2 is independently H, alkyl, alkenyl, alkoxy, halo, hydroxy, trifluoromethyl, amino, alkylamino, cyano and nitro; R. sub. 3 is carbalkoxy, carboxamide alkanoyl, trifluoromethyl and cyano; and Ar is heteroaryl or ##STR2## wherein R. sub. 4 and R. sub. 5 have the same meaning as each of R, R. sub. 1 and R. sub. 2 ; and acid addition salts thereof have cardiotonic and hypertensive activity.

44353952, Mar 6, 1984

Mar 3, 1983

6/471958

Bernard Loev - Scarsdale NY
Howard Jones - Ossining NY
James R. Shroff - Riverside CT

USV Pharmaceutical Corporation - Tarrytown NY

A61K 31535
C07D41306

4242485

Compounds of the formula: ##STR1## which are useful as antihypertensive agents are disclosed.

42580420, Mar 24, 1981

Apr 11, 1980

6/139367

Bernard Loev - Scarsdale NY
James R. Shroff - Riverside CT

USV Pharmaceutical Corporation - Tuckahoe NY

A61K 31535
C07D29514

4242485

Antihypertensive compounds of the formula ##STR1## wherein R. sub. 5 is H, alkyl, aryl, halo, lower alkoxy, nitro amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, acyloxy, methanesulfonyl, alkylamino or acylamino; and each R. sub. 1 and R. sub. 2 is alkyl; wherein the alkyl, alkoxy and aryl groups contain up to 10 carbon atoms and non-toxic, pharmaceutically-acceptable acid addition salts thereof.