US Patent:
20070249610, Oct 25, 2007
Inventors:
Gerard Crispino - Lawrenceville NJ, US
Mourad Hamedi - Eatontown NJ, US
Thomas LaPorte - Kendall Park NJ, US
John Thornton - Newtown PA, US
Jaan Pesti - Yardley PA, US
Zhongmin Xu - Princeton NJ, US
Paul Lobben - Lawrenceville NJ, US
David Leahy - Morristown NJ, US
Jale Muslehiddinoglu - Hightstown NJ, US
Chiajen Lai - Kendall Park NJ, US
Lori Spangler - Churchville PA, US
Robert Discordia - Pennington NJ, US
International Classification:
A61K 31/53
C07D 487/04
Abstract:
The invention relates to an improved process for preparing [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.