Inventors:
Wendy Lea Corbett - Randolph NJ, US
Joseph Samuel Grimsby - Morganville NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
Robert Francis Kester - West Orange NJ, US
Paige Erin Mahaney - Pottstown PA, US
Jagdish Kumar Racha - Iselin NJ, US
Ramakanth Sarabu - Towaco NJ, US
Ka Wang - Wayne NJ, US
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
C07D 241/20
C07D 213/75
C07D 277/46
C07D 409/12
US Classification:
51425505, 514336, 514371, 514459, 514460, 514471, 544336, 5462821, 548195, 549419, 549493, 549494, 549495, 549496
Abstract:
2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.