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Jacob M Janey

from Bronx, NY
Age ~49
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Also known as:
Jake M Janey, Jake Kaney
Related to:
Joseph S Janey, 46
Connected to:
Catherine A Janey, 56Douglas P Janey, 54Edgar W Janey, 100Rochelle S Janey, 63Trudy Janey, 86Jeffrey Janezick, 54Joseph G Janezic, 90Kristopher J Janezic, 36Loretta J Janezic, 76Michele M Janezic, 49

Jacob Janey Phones & Addresses

  • Bronx, NY
  • Sudbury, MA
  • 50 W 72Nd St APT 1505, New York, NY 10023 (917) 420-0451
  • 12 Oxford St, Cambridge, MA 02138
  • Somerville, MA
  • Waltham, MA
  • Chicago, IL
  • Saint Clair, MN
  • Good Thunder, MN
  • 50 W 72Nd St APT 1505, New York, NY 10023

Work

Company: Merck Position: Sr. research chemist

Education

Degree: Ph.D. School / High School: Harvard University 1998 to 2003 Specialities: Organic Chemistry

Awards

• Process Researc...

Industries

Pharmaceuticals

Resumes

Resumes

Jacob Janey Photo 1

Sr. Research Chemist At Merck

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Position:
Sr. Research Chemist at Merck
Location:
Greater New York City Area
Industry:
Pharmaceuticals
Work:
Merck
Sr. Research Chemist
Harvard University 1998 - 2003
Graduate Student
Education:
Harvard University 1998 - 2003
Ph.D., Organic Chemistry University of Chicago 1994 - 1998
B.S., Chemistry
Honor & Awards:
• Process Research Innovation Award (Januvia Transaminase), 2009, • Merck Research Laboratories: Best Overall Project, 2009, • Merck Sigma Awards: Best Innovation, 2009, • ACS Presidential Green Chemistry Award Winner, 2010

Publications

Us Patents

Transaminase Biocatalysts

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US Patent:
8293507, Oct 23, 2012
Filed:
Feb 26, 2010
Appl. No.:
12/714397
Inventors:
Christopher Savile - Sunnyvale CA, US
Emily Mundorff - Belmont CA, US
Jeffrey C. Moore - Westfield NJ, US
Paul N. Devine - Tinton Falls NJ, US
Jacob M. Janey - New York City NY, US
Assignee:
Codexis, Inc. - Redwood City CA
International Classification:
C12P 17/18
C12N 9/10
US Classification:
435119, 435128, 435193
Abstract:
The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Process For Making Glucocorticoid Receptor Ligands

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US Patent:
20100228036, Sep 9, 2010
Filed:
Oct 20, 2008
Appl. No.:
12/739483
Inventors:
Qinghao Chen - Edison NJ, US
Shinji Fujimori - Rahway NJ, US
Jacob M. Janey - New York NY, US
John Limanto - Rahway NJ, US
Rafik Naccache - Montreal, CA
Andrew F. Nolting - Trenton NJ, US
Neil Strotman - Monmouth Junction NJ, US
Lushi Tan - Edison NJ, US
Mark Weisel - Stewartsville NJ, US
International Classification:
C07D 231/54
US Classification:
5483591
Abstract:
The invention encompasses a process for making 2-[1-phenyl-5-hydroxy-4alpha-methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives, which are glucocorticoid receptor ligands, useful for the treatment of inflammatory and immunological diseases.

Renin Inhibitors

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US Patent:
20120035214, Feb 9, 2012
Filed:
Apr 1, 2010
Appl. No.:
13/262781
Inventors:
Daniel J. McKay - Lexington MA, US
Melissa Arbour - Pierrefonds, CA
Renee Aspiotis - Kirkland, CA
Austin Chen - San Diego CA, US
Pierre-Andre Fournier - Vaudreuil-Dorion, CA
Michel Gallant - Pierrefonds, CA
Yongxin Han - Kirkland, CA
Helene Juteau - St. Laurent, CA
Patrick Lacombe - Montreal, CA
Sebastien Laliberte - St. Lazare, CA
Sophie Lauzon - St. Lazare, CA
Carmela Molinaro - Lansdale PA, US
Paul O'Shea - Princeton NJ, US
Yeeman Ramtohul - Pierrefonds, CA
Daniel Simard - Brookline MA, US
Dwight MacDonald - L'lle Bizard, CA
Bruce Mackay - Dollard-des-Ormeaux, CA
Christophe Mellon - L'lle Bizard, CA
Krista Morley - Brossard, CA
Chit Tsui - Toronto, CA
Sarah Jennifer Dolman - New York NY, US
Greg Hughes - Scotch Plains NJ, US
Jacob Janey - New York NY, US
Assignee:
Merck Canada Inc. - Kirkland
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/451
C07D 401/04
C07D 401/10
C07D 211/26
C07D 211/28
C07D 401/12
A61K 31/4545
A61K 31/454
A61P 9/12
A61P 9/04
A61P 9/10
A61P 27/06
A61P 25/22
A61P 25/00
A61P 13/12
C07D 211/22
US Classification:
514318, 546236, 546194, 546199, 546234, 546232, 546211, 546229, 514317, 514322, 514331, 514326
Abstract:
The present invention relates to biaryl piperidine-based renin inhibitor compounds, and their use in treating cardiovascular events and renal insufficiency.

Transaminase Biocatalysts

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US Patent:
20120329108, Dec 27, 2012
Filed:
Sep 5, 2012
Appl. No.:
13/604323
Inventors:
Christopher Savile - Sunnyvale CA, US
Emily Mundorff - Poughkeepsie NY, US
Jeffrey C. Moore - Westfield NY, US
Paul N. Devine - Tinton Falls NY, US
Jacob M. Janey - New York NY, US
Assignee:
CODEXIS, INC. - Redwood City CA
International Classification:
C12N 9/10
C12N 15/70
C12P 17/18
C12P 13/00
C12P 13/02
C12N 15/54
C12N 1/21
US Classification:
435119, 435193, 536 232, 4353201, 43525233, 435128, 435129
Abstract:
The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Process For Preparing Aminocyclohexyl Ether Compounds

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US Patent:
20130149751, Jun 13, 2013
Filed:
Aug 8, 2011
Appl. No.:
13/817274
Inventors:
John Limanto - Rahway NJ, US
Gregory L. Beutner - Green Brook NJ, US
Jingjun Yin - Green Brook NJ, US
Artis Klapars - Edison NJ, US
Eric R. Ashley - Fanwood NJ, US
Hallena R. Strotman - Somerset NJ, US
Matthew D. Truppo - Bradley Beach NJ, US
Cheol K. Chung - Westfield NJ, US
Gregory Hughes - Scotch Plains NJ, US
Zhijian Liu - Kendall Park NJ, US
Brendan Grau - Warrington NJ, US
Jacob Janey - New York NY, US
International Classification:
C12P 17/10
US Classification:
435121, 564443
Abstract:
The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.

Biocatalysts And Methods For The Synthesis Of (1R,2R)-2-(3,4-Dimethoxyphenethoxy)Cyclohexamine

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US Patent:
20130164794, Jun 27, 2013
Filed:
Aug 8, 2011
Appl. No.:
13/817295
Inventors:
John Limanto - Metuchen NJ, US
Gregory Beutner - Green Brook NJ, US
Brendan Grau - Warrington PA, US
Jacob Janey - New York NY, US
Artis Klapars - Edison NJ, US
Eric Ashley - Fanwood NJ, US
Hallena R. Strotman - Monmouth Junction NJ, US
Matthew D. Truppo - Ocean Township NJ, US
Gregory Hughes - Scotch Plains NJ, US
Fabien L. Cabirol - Dusseldorf, DE
Anupam Gohel - Singapore, SG
Steven J. Collier - Singapore, SG
Jack Liang - San Mateo CA, US
Marissa Mock - Moorpark CA, US
Emily Mundorff - Poughkeepsie NY, US
Scott Novick - Palo Alto CA, US
Derek Smith - Singapore, SG
Assignee:
CODEXIS, INC. - Redwood City CA
International Classification:
C12N 9/10
US Classification:
435128, 536 232, 435193, 4353201, 4352523, 43525233, 43525235, 43525411, 4352542, 43525421, 43525423, 435348, 435325, 435358, 435365, 435352, 435366, 435419
Abstract:
The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.

Engineered Imine Reductases And Methods For The Reductive Animation Of Ketone And Amine Compounds.

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US Patent:
20130302859, Nov 14, 2013
Filed:
May 9, 2013
Appl. No.:
13/890944
Inventors:
CHEN Haibin - SG, SG
Steven J. Collier - Lexington MA, US
Jovana NAZOR - Santa Clara, US
Joly SUKUMARAN - SG, SG
Derek SMITH - Singapore, SG
Jeffrey C. MOORE - Westfield NJ, US
Gregory HUGHES - Scotch Plains NJ, US
Jacob JANEY - New York NY, US
Gjalt HUISMAN - San Carlos CA, US
Scott NOVICK - Palo Alto CA, US
Nicholas AGARD - San Francisco CA, US
Oscar ALVIZO - Freemont CA, US
Gregory COPE - Menlo Park CA, US
Wan Lin YEO - Singapore, SG
Stephanie NG - Redwood City CA, US
Assignee:
CODEXIS,INC. - Redwood City CA
International Classification:
C12N 9/00
US Classification:
435122, 435191, 536 232, 4353201, 435128, 435121, 4352523, 43525233, 43525231, 43525235, 43525411, 4352542, 43525421, 43525423, 435348, 435358, 435365, 435352, 435419
Abstract:
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Engineered Imine Reductases And Methods For The Reductive Amination Of Ketone And Amine Compounds

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US Patent:
20220315961, Oct 6, 2022
Filed:
Jun 2, 2022
Appl. No.:
17/830650
Inventors:
- Redwood City CA, US
Steven J. Collier - Concord MA, US
Jovana Nazor - Milpitas CA, US
Joly Sukumaran - Singapore, SG
Derek Smith - Singapore, SG
Jeffrey C. Moore - Westfield NJ, US
Gregory Hughes - Scotch Plains NJ, US
Jacob Janey - New York NY, US
Gjalt W. Huisman - Redwood City CA, US
Scott J. Novick - Palo Alto CA, US
Nicholas J. Agard - San Francisco CA, US
Oscar Alvizo - Fremont CA, US
Gregory A. Cope - Menlo Park CA, US
Wan Lin Yeo - Singapore, SG
Stefanie Ng Minor - Redwood City CA, US
International Classification:
C12P 13/02
C12P 13/00
C12P 17/18
C12P 13/04
C12P 13/06
C12P 17/10
C12P 17/12
C12P 17/16
C12N 9/06
Abstract:
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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Jacob M Janey from Bronx, NY, age ~49 Get Report