Inventors:
- San Clemente CA, US
James Shiah - San Clemente CA, US
Jack Xie - San Clemente CA, US
Jia-Ying Yang - San Clemente CA, US
International Classification:
A61K 9/00
A61K 31/4439
A61K 47/34
Abstract:
The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.
