Search

Isaac J Rondon

from San Francisco, CA
Age ~68
Get Report
Also known as:
Isaac Dr Rondon, Isaac Rondon Revocable, Isaac Rondon Trs, Issac J Rondon, Isaac Rondu, Isaac N
Phone and address:
647 Grand View Ave APT 2, San Francisco, CA 94114
(415) 235-8913
Related to:
Maryjo J Murray, 50
Connected to:
Angelica Rondon, 102Arturo Rondon, 67Delia Rondon, 85Efrain Rondon, 90Felix O Rondon, 68Fior D Rondon, 66Gabriel Rondon, 46Jaime Rondon, 68Jhon F Rondon, 47Liliam Rondon, 62

Isaac Rondon Phones & Addresses

  • 647 Grand View Ave APT 2, San Francisco, CA 94114 (415) 235-8913
  • Miami Beach, FL
  • New Orleans, LA
  • 90 Saint Botolph St, Boston, MA 02116 (617) 262-9376

Resumes

Resumes

Isaac Rondon Photo 1

Senior Director

View page
Location:
San Francisco, CA
Industry:
Biotechnology
Work:
Pfizer
Senior Director
Pfizer Apr 2011 - May 2017
Director
Xoma Jul 2010 - Mar 2011
Director of Genetic Engineering
Xoma Apr 2009 - Jul 2010
Associate Director of Genetic Engineering
Xoma 2007 - 2009
Senior Scientist Ii of Antibody Discovery and Engineering
Education:
Harvard Medical School 1994 - 1997
Tulane University School of Medicine 1988 - 1992
Doctorates, Doctor of Philosophy, Pharmacology Louisiana State University 1976 - 1980
Bachelors, Bachelor of Science, Biochemistry
Skills:
Molecular Biology
High Throughput Screening
Phage Display
Antibodies
Protein Chemistry
Biotechnology
Monoclonal Antibodies
Clinical Development
Protein Expression
Drug Discovery
Technology Transfer
Cell Culture
Fda
Pharmaceutical Industry
Gmp
Validation
Biomarker Discovery
Isaac Rondon Photo 2

Isaac Rondon

View page

Publications

Us Patents

Binding Peptides For Carcinoembryonic Antigen (Cea)

View page
US Patent:
6919424, Jul 19, 2005
Filed:
Apr 3, 2001
Appl. No.:
09/825517
Inventors:
Isaac Jesus Rondon - Boston MA, US
Robert Charles Ladner - Ijamsville MD, US
Assignee:
Dyax Corp. - Cambridge MA
International Classification:
C07K005/00
C07K014/00
C07K016/00
C07K007/00
US Classification:
530300, 530326, 530350, 5303871
Abstract:
The present invention provides binding moieties for CEA, which have a variety of uses wherever detecting, isolating or localizing CEA, and particularly CEA as opposed to cross-reactive antigens such as NCA, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding CEA, which is overexpressed in adenocarcinomas of endodermally derived digestive system epithelia and fetal colon. Such polypeptides and disclosed derivatives are useful, e. g. , as imaging agents for CEA-expressing tumors.

Binding Peptides For Carcinoembryonic Antigen (Cea)

View page
US Patent:
7438890, Oct 21, 2008
Filed:
Jan 26, 2005
Appl. No.:
11/045477
Inventors:
Isaac J. Rondon - San Francisco CA, US
Robert Charles Ladner - Ijamsville MD, US
Assignee:
Dyax Corp. - Cambridge MA
International Classification:
A61K 38/00
A61K 38/04
A61K 38/08
A61K 38/10
A61K 38/12
A61K 49/00
A61K 51/08
C07K 4/00
C07K 7/00
C07K 7/04
C07K 9/00
C07K 11/00
US Classification:
424 169, 424 91, 424 934, 436 64, 514 2, 514 13, 514 14, 514 15
Abstract:
The present invention provides binding moieties for CEA, which have a variety of uses wherever detecting, isolating or localizing CEA, and particularly CEA as opposed to cross-reactive antigens such as NCA, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding CEA, which is overexpressed in adenocarcinomas of endodermally derived digestive system epithelia and fetal colon. Such polypeptides and disclosed derivatives are useful, e. g. , as imaging agents for CEA-expressing tumors.

Conformation Specific Antibodies

View page
US Patent:
7927591, Apr 19, 2011
Filed:
Feb 22, 2005
Appl. No.:
10/589956
Inventors:
Edward H. Cohen - Belmont MA, US
Isaac J. Rondon - San Francisco CA, US
Timothy A. Springer - Newton MA, US
Motomu Shimaoka - Brookline MA, US
Assignee:
The CBR Institute for Biomedical Research, Inc. - Boston MA
International Classification:
A61K 39/395
C07K 16/46
C07K 16/28
US Classification:
4241331, 4241431, 5303873, 53038822, 5303887
Abstract:
The disclosure provides, inter alia, binding proteins (e. g. , antibodies) that bind to an integrin in an activated conformation, e. g. , activated LFA-1 (“aLFA-1”), e. g. , relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e. g. , inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e. g. , an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.

Conformation Specific Antibodies

View page
US Patent:
8247185, Aug 21, 2012
Filed:
Mar 8, 2011
Appl. No.:
13/042623
Inventors:
Edward H. Cohen - Belmont MA, US
Isaac J. Rondon - San Francisco CA, US
Timothy A. Springer - Newton MA, US
Motomu Shimaoka - Brookline MA, US
Assignee:
DYAX Corp. - Cambridge MA
The CBR Institute for Biomedical Research, Inc. - Boston MA
International Classification:
C12Q 1/68
A61K 39/395
US Classification:
435 71, 4241301, 4241431, 4241441
Abstract:
The disclosure provides, inter alia, binding proteins (e. g. , antibodies) that bind to an integrin in an activated conformation, e. g. , activated LFA-1 (“aLFA-1 ”), e. g. , relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e. g. , inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e. g. , an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.

Triple Tag Sequence And Methods Of Use Thereof

View page
US Patent:
8546307, Oct 1, 2013
Filed:
Oct 2, 2009
Appl. No.:
12/572877
Inventors:
Isaac Rondon - San Francisco CA, US
Marina Roell - Concord CA, US
Daniel Bedinger - Vacaville CA, US
Assignee:
XOMA Technology, Ltd. - Berkeley CA
International Classification:
C40B 30/04
US Classification:
506 9
Abstract:
The present disclosure relates to novel triple tag sequences that may comprise a 6× histidine tag, a c-myc tag and a V5 tag. The present disclosure also provides polynucleotides, proteins, vectors and host cells that comprise the triple tag sequence of the present disclosure, including libraries of such polynucleotides, proteins, vectors and host cells. The novel triple tag sequences of the present disclosure may be used in phage display vectors and phage libraries and in methods for detection, screening, capture, purification, quantitation, and/or recovery of proteins of interest to which they are linked. Proteins of interest include antibodies such as single chain antibodies, single chain antibodies, and Fab fragments of antibodies or peptides such as non-antibody peptides.

Triple Tag Sequences And Methods Of Use Thereof

View page
US Patent:
8546308, Oct 1, 2013
Filed:
Sep 26, 2011
Appl. No.:
13/244871
Inventors:
Isaac Rondon - Berkeley CA, US
Marina Roell - Berkeley CA, US
Daniel Bedinger - Berkeley CA, US
Assignee:
XOMA Technology, Ltd. - Berkeley CA
International Classification:
C40B 30/04
C40B 40/02
C40B 40/08
US Classification:
506 9, 506 14
Abstract:
The present disclosure relates to novel triple tag sequences that may comprise a 6× histidine tag, a c-myc tag and a V5 tag. The present disclosure also provides polynucleotides, proteins, vectors and host cells that comprise the triple tag sequence of the present disclosure, including libraries of such polynucleotides, proteins, vectors and host cells. The novel triple tag sequences of the present disclosure may be used in phage display vectors and phage libraries and in methods for detection, screening, capture, purification, quantitation, and/or recovery of proteins of interest to which they are linked. Proteins of interest include antibodies such as single chain antibodies, single chain antibodies, and Fab fragments of antibodies or peptides such as non-antibody peptides.

Binding Molecules For Fc-Region Polypeptides

View page
US Patent:
20030199671, Oct 23, 2003
Filed:
Apr 18, 2002
Appl. No.:
10/125869
Inventors:
Isaac Rondon - Boston MA, US
Arthur Ley - Newton MA, US
Mark Stochl - N. Attleboro MA, US
Thomas Ransohoff - Lexington MA, US
M. Potter - Acton MA, US
Marilou Potter - Acton MA, US
International Classification:
C07K007/64
US Classification:
530/317000
Abstract:
Binding molecules for detecting or isolating immunoglobulin Fc-region polypeptides are described, together with methods of use thereof. Preferred Fc-region binding polypeptides, recombinant bacteriophage expressing Fc-region binding polypeptides, and separation media exhibiting such polypeptides are particularly disclosed.

Cd44-Binding Ligands

View page
US Patent:
20040110933, Jun 10, 2004
Filed:
Sep 15, 2003
Appl. No.:
10/663244
Inventors:
Isaac Rondon - San Francisco CA, US
Albert Edge - Newton MA, US
Rachel Kent - Boxborough MA, US
Assignee:
DYAX CORPORATION
International Classification:
C07K016/28
US Classification:
530/388220
Abstract:
The invention provides, inter alia, CD44-binding proteins, including CD4-binding antibodies, antibody fragments, and pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such proteins. Methods of using the proteins to detect CD44 or to modulate a CD44-expressing cell, e.g., in a subject, are also described.
Control profile
Isaac J Rondon from San Francisco, CA, age ~68 Get Report