US Patent:
20060194301, Aug 31, 2006
Inventors:
Bhupendra Doctor - Potomac MD, US
Ashima Saxena - Fairfax VA, US
Wei Sun - Gaithersburg MD, US
Chunyuan Luo - North Potomac MD, US
Prasanthi Tipparaju - Rockville MD, US
Irwin Koplovitz - Bel Air MD, US
David Lenz - Belcamp MD, US
Michelle Ross - Edgewood MD, US
International Classification:
C12N 9/00
C12N 9/16
Abstract:
Disclosed herein are methods for the large-scale preparation of human butyrylcholinesterase (HuBChE) preparations from Cohn Fraction IV-4. As disclosed, the methods provide HuBChE preparations that are about 99% or more pure with recovery yields of about 60%. Also disclosed are the pharmacokinetics, safety and toxicity, stability and efficacy of the HuBChE preparations.