Inventors:
Prabhati Ray - Potomac MD
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
G01N 33573
US Classification:
435 74, 435212, 435219, 435220, 435 681, 435 692, 424 92, 530412
Abstract:
This invention relates to the discovery that toxicity to mustard may be evaluated by diagnostic test means disclosed herein. Upon electrophoretic separation (sodium dodocyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE)) of buffered extract of human skin cells (normal human epidermal keratinocytes (NHEK)) which had been exposed to mustard-type chemical compounds a band at approximately 50,000 to 80,000 daltons molecular weight was found. The protein band constitutes a biomarker.