Huangpin Ben Hsieh

7121157, Oct 17, 2006

Aug 6, 2004

10/913940

Meng H. Lean - Santa Clara CA, US
Huangpin Ben Hsieh - Mountain View CA, US
Armin R. Völkel - Mountain View CA, US
Peter Kiesel - Palo Alto CA, US
Noble Johnson - Menlo Park CA, US

Palo Alto Research Center Incorporated - Palo Alto CA

G01N 1/04
G01N 1/22

7386471, 7386321

Disclosed is a compact, non-contacting device for collecting samples, and particularly minute quantities of bio-agents or particulates, from a surface. The device vibrates a region of a target surface containing the sample and collects the sample on an electrically charged pin array. The sample can be later released to a detector or other instrumentation for subsequent analysis.

7122799, Oct 17, 2006

Dec 18, 2003

10/739706

Huangpin Ben Hsieh - Mountain View CA, US
Michael A. Kneissl - Mountain View CA, US

Palo Alto Research Center Incorporated - Palo Alto CA

G01J 5/02

25033912, 2504581, 2504611, 2504612

A system for conducting a polymerase chain reaction (PCR) assay upon a collection of samples is disclosed. The PCR assay is performed by absorption detection. The system includes a multi-well plate which is adapted to retain a collection of sample wells. This system includes a thermal cycler for the multi-well plate. The system additionally includes a collection of photodetectors, and a corresponding number of light sources. The light sources are positioned such that light emitted from each of the respective light sources passes through a corresponding well retained in the multi-well plate and to a corresponding photodetector. The system also includes a processor or other means for analyzing the output signals from the photodetectors. In certain versions of the system, ultra-violet light is used.

7126134, Oct 24, 2006

Aug 19, 2004

10/921556

Meng H. Lean - Santa Clara CA, US
Francisco E. Torres - San Jose CA, US
Huangpin Ben Hsieh - Mountain View CA, US
Armin R. Völkel - Mountain View CA, US
Bryan Preas - Palo Alto CA, US
Scott A. Elrod - LaHonda CA, US
John S. Fitch - Los Altos CA, US
Richard H. Bruce - Los Altos CA, US

Palo Alto Research Center Incorporated - Palo Alto CA

G21K 5/10

25044211

A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.

7150813, Dec 19, 2006

Jun 12, 2003

10/460724

Meng H. Lean - Santa Clara CA, US
Huangpin Ben Hsieh - Mountain View CA, US
John S. Fitch - Los Altos CA, US
Armin R. Völkel - Mountain View CA, US
Bryan Preas - Palo Alto CA, US
Scott Elrod - La Honda CA, US
Richard H. Bruce - Los Altos CA, US
Eric Peeters - Fremont CA, US
Frank Torres - San Jose CA, US
Michael Chabinyc - Mountain View CA, US

Palo Alto Research Center Incorporated - Palo Alto CA

B01D 57/02

204547, 204643, 204450, 204600

Various gel electrophoretic assemblies and techniques are disclosed for providing unique isoelectric focusing (IEF) strategies. Several particular systems, assemblies and methods are provided that significantly reduce processing time, enable the use of reduced operating voltages, and produce analytical results with improved resolution.

7156970, Jan 2, 2007

Jun 12, 2003

10/459799

Meng H. Lean - Santa Clara CA, US
Huangpin Ben Hsieh - Mountain View CA, US
John S. Fitch - Los Altos CA, US
Armin R. Völkel - Mountain View CA, US
Bryan Preas - Palo Alto CA, US
Scott Elrod - La Honda CA, US
Richard H. Bruce - Los Altos CA, US
Eric Peeters - Fremont CA, US
Frank Torres - San Jose CA, US
Michael Chabinyc - Mountain View CA, US

Palo Alto Research Center Incorporated - Palo Alto CA

G01N 27/447
G01N 27/453

204547, 204643

Various traveling wave grids and electrophoretic systems, and electrode assemblies using such grids, are disclosed. A configuration in which a voltage potential is used to load a biomolecule sample against a grid is disclosed. A unique strategy of using multiple, reconfigurable grids in such systems is also described. The strategy involves initially conducting a broad protein separation and then selectively tailoring one or more grids, and conducting one or more secondary processing operations. Related strategies and specific methods are additionally disclosed for separating samples of biomolecules and components thereof using the noted systems, assemblies, and grids.

7163611, Jan 16, 2007

Dec 3, 2003

10/727289

Armin R. Völkel - Mountain View CA, US
Meng H. Lean - Santa Clara CA, US
Huangpin Ben Hsieh - Mountain View CA, US
Jurgen Daniel - Mountain View CA, US

Palo Alto Research Center Incorporated - Palo Alto CA

B01D 57/02

204547, 204643

Several traveling wave grid systems are disclosed that may be used to concentrate and form highly localized regions of bio-agents or other charged species. In addition, specific detection systems are described that enable currently available detectors and sensors, including those to be developed in the future, to be used for measuring the presence and concentration of certain bio-agents or charged particles, which otherwise are present at concentrations too low to readily detect or measure.

7248361, Jul 24, 2007

Dec 22, 2005

11/315797

Peter Kiesel - Palo Alto CA, US
Oliver Wolst - Nürtingen, DE
Michael Kneissl - Berlin, DE
Huangpin Ben Hsieh - Mountain View CA, US
Oliver Schmidt - Palo Alto CA, US

Palo Alto Research Center Incorporated - Palo Alto CA

G01N 21/64

356318, 2504581

A sample detection system including an anti-resonant waveguide, including a sample having a first index of refraction, a top layer and a substrate surrounding the sample, where the top layer has a second index of refraction, and the substrate has a third index of refraction. The second index of refraction, and the third index of refraction are both greater than the first index of refraction. A detection device of the system includes a low power light source used to direct light into the sample and generate an anti-resonant optical mode in the sample, and an analyzing system to detect the interaction of the light propagating in the sample.

7277569, Oct 2, 2007

Jul 9, 2003

10/616366

Richard H. Bruce - Los Altos CA, US
Douglas N. Curry - Menlo Park CA, US
Robert T. Krivacic - San Jose CA, US
Huangpin B. Hsieh - Mountain View CA, US

Palo Alto Research Center Incorporated - Palo Alto CA

G06K 9/00

382133, 382128, 382132

In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample.