Ho June Lee

D3645568, Nov 28, 1995

Aug 30, 1994

D/027836

Ho Lee - Bowie MD
David M. Hurr - Falls Church VA

Snoloc Corporation - Upper Marlboro MD

D 8499

56339828, May 27, 1997

Oct 21, 1996

8/734210

Kalyan Ganesan - Germantown MD
Ho Lee - San Diego CA
Prabhat Gupta - Germantown MD

Hughes Electronics - Los Angeles CA

G10L 900
G10L 506

395 242

The perception of speech processed by a CELP based coder, such as a VSELP coder, when operating in noisy background conditions is improved by removing swirl artifacts during silence periods. This is done by removing the low frequency components of the input signal when no speech is detected. A speech activity detector distinguishes between a periodic signal, like speech, and a non-periodic signal, like noise by using most of the VSELP coder internal parameters to determine the speech or non-speech conditions. To prevent the VSELP coder from determining pitches for non-periodic signals, a high pass filter is applied to the input signal to remove the pitch information for which the VSELP coder searches.

20200230218, Jul 23, 2020

Aug 30, 2019

16/556957

- Seoul, KR
Jeong Kuen Song - Gaithersburg MD, US
Seung-Wook Shin - Clarksburg MD, US
Kwan Hee Lee - Las Vegas NV, US
Ho June Lee - Potomac MD, US

L & J Bio Co., Ltd. - Seoul

A61K 38/57
A61K 38/17
A61P 25/28
A61K 38/38
A61K 38/46
A61K 38/50

The present application discloses a method for treating a protein deficiency in the central nervous system of a subject in need thereof, comprising systemically administering to the subject a therapeutically effective dose of a fusion polypeptide comprising the first protein, wherein the fusion polypeptide comprises: (a) the first protein; (b) a second protein that provides extended circulation-lifetime in vivo and (c) blood brain barrier crossing facilitating peptide; wherein the fusion polypeptide crosses the blood brain barrier (BBB).