Inventors:
Hemant Thatte - Medfield MA, US
Patrick Treanor - Dedham MA, US
Shukri F. Khuri - Needham MA, US
Randa Khuri, legal representative - Needham MA, US
Laki Rousou - New York NY, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
The United States of America as Represented by the Department of Veterans Affairs - Washington DC
International Classification:
A01N 1/00
Abstract:
Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.