Search

Heike S Radeke

from Apex, NC
Age ~54
Get Report
Also known as:
Heike S Redeke, Hieke Radeke, Radeke S Heike
Connected to:
Darrin V Radeke, 59Nancy E Radekopf, 65Brian Radel, 43Cory M Radel, 43Joan M Radel, 65John C Radel, 44Jordan M Radel, 32Joshua A Radel, 47Shiella D Radel, 60Barry L Radell, 77

Heike Radeke Phones & Addresses

  • Apex, NC
  • Dedham, MA
  • Newton, MA
  • 15 Seaver Farm Ln, South Grafton, MA 01560

Work

Company: Lantheus (discovery medicinal chemistry) - North Billerica, MA 2008 Position: Senior research investigator ii

Education

School / High School: Boston College- Chestnut Hill, MA Sep 1998 Specialities: Ph.D. in Organic Chemistry

Skills

Drug Discovery • Medicinal Chemistry • Chemistry • Clinical Development • Drug Design • Oncology • Pharmaceutical Industry • Biotechnology • Organic Chemistry • Patents • In Vivo • Technology Transfer • High Throughput Screening • Adme • Cro • Assay Development • Drug Development • Biomarker Discovery • Cardiovascular Disease • Validation • Pharmacokinetics • Hit To Lead Optimization • Parallel Synthesis • Positron Emission Tomography • Ind Filing • Central Nervous System Diseases • Cross Functional Team Leadership • Project Management • Translational Chemistry • Pharmacophore Modeling • Lims • Technology Specialist • Process Chemistry • Cro Management • Product In Licensing • Program Strategy Development • Imaging Technology • Pet Imaging • Preclinical Project Assessment

Languages

English • German • French

Industries

Law Practice

Resumes

Resumes

Heike Radeke Photo 1

Patent Agent

View page
Location:
2077 Pineola Bog Trl, Apex, NC
Industry:
Law Practice
Work:
Myers Bigel, Pa Mar 2018 - Apr 2019
Patent Agent
Katten Muchin Rosenman Llp Mar 2018 - Apr 2019
Patent Agent
Womble Bond Dickinson (Us) Llp Oct 2015 - Mar 2018
Patent Agent
Mintz Levin Sep 2013 - Oct 2015
Technology Specialist In Life Sciences and Intellectual Property and Technology Litigation
Lantheus Medical Imaging 2008 - 2013
Senior Research Investigator Ii
Education:
Boston College 1993 - 1998
Doctorates, Doctor of Philosophy, Biochemistry, Organic Chemistry Binghamton University 1989 - 1993
Bachelors, Bachelor of Science, Chemistry
Skills:
Drug Discovery
Medicinal Chemistry
Chemistry
Clinical Development
Drug Design
Oncology
Pharmaceutical Industry
Biotechnology
Organic Chemistry
Patents
In Vivo
Technology Transfer
High Throughput Screening
Adme
Cro
Assay Development
Drug Development
Biomarker Discovery
Cardiovascular Disease
Validation
Pharmacokinetics
Hit To Lead Optimization
Parallel Synthesis
Positron Emission Tomography
Ind Filing
Central Nervous System Diseases
Cross Functional Team Leadership
Project Management
Translational Chemistry
Pharmacophore Modeling
Lims
Technology Specialist
Process Chemistry
Cro Management
Product In Licensing
Program Strategy Development
Imaging Technology
Pet Imaging
Preclinical Project Assessment
Languages:
English
German
French
Heike Radeke Photo 2

Heike Radeke South Grafton, MA

View page
Work:
Lantheus (Discovery Medicinal Chemistry)
North Billerica, MA
2008 to Apr 2013
Senior Research Investigator II
Bristol-Myers Squibb (Discovery Medicinal Chemistry, Medical Imaging Division)
North Billerica, MA
2003 to 2008
Senior Research Investigator I
NeoGenesis Pharmaceuticals (Medicinal Chemistry)
Cambridge, MA
2002 to 2003
Senior Scientist
Sepracor, Inc (Drug Discovery)
Marlborough, MA
2000 to 2002
Senior Scientist
Sepracor, Inc (Drug Discovery)
Marlborough, MA
1998 to 2002
Scientist
Boston College
Chestnut Hill, MA
1993 to 1998
Research Assistant
Education:
Boston College
Chestnut Hill, MA
Sep 1998
Ph.D. in Organic Chemistry
State University of New York at Binghamton
Binghamton, NY
May 1993
B.S. in Chemistry

Publications

Us Patents

Thiazole And Other Heterocyclic Ligands For Mammalian Dopamine, Muscarinic And Serotonin Receptors And Transporters, And Methods Of Use Thereof

View page
US Patent:
6699866, Mar 2, 2004
Filed:
Apr 12, 2002
Appl. No.:
10/123089
Inventors:
Gregory D. Cuny - Somerville MA
James R. Hauske - Concord MA
Michele L. R. Heffernan - Worcester MA
Joanne M. Holland - Brookline MA
Paul E. Persons - Westborough MA
Heike Radeke - South Grafton MA
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K 31535
US Classification:
5142368, 51425402, 514326, 514370, 544133, 544137, 544369, 546209, 548190
Abstract:
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various mammalian cellular receptors, including G-protein coupled receptors. A third aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for mammalian dopamine, muscarinic or serotonin receptors or transporters. Another aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for mammalian dopamine, muscarinic or serotonin receptors. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimers disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinsons disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilsons disease, Tourettes syndrome, psychiatric disorders, stroke, senile dementia, peptic ulcers, pulmonary obstruction disorders, and asthma.

Antipsychotic Sulfonamide-Heterocycles, And Methods Of Use Thereof

View page
US Patent:
6703383, Mar 9, 2004
Filed:
Sep 12, 2001
Appl. No.:
09/951137
Inventors:
Xinhe Wu - Marlborough MA
Brian M. Aquila - Marlborough MA
Liming Shao - Lincoln MA
Heike Radeke - Dedham MA
Gregory D. Cuny - Hudson MA
James R. Hauske - Concord MA
Roger L. Xie - Natrick MA
Assignee:
Sepracor, Inc. - Malborough MA
International Classification:
A61K 3133
US Classification:
514183, 514315, 514331, 514277, 514332, 514337, 514350, 514354, 514353, 514357, 514705, 514603
Abstract:
One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds comprising a sulfonamide moiety, and the screening of those libraries for biological activity, e. g. , in animal models of psychosis.

Piperidine-Piperazine Ligands For Neurotransmitter Receptors

View page
US Patent:
6713479, Mar 30, 2004
Filed:
Mar 1, 2002
Appl. No.:
10/087609
Inventors:
Paul E. Persons - Westborough MA
Heike Radeke - South Grafton MA
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K 31496
US Classification:
51425301, 51425313, 544360
Abstract:
One aspect of the present invention relates to piperidine-piperazine compounds generically represented by A. A second aspect of the present invention relates to the use of the piperidine-piperazine compounds as ligands for various mammalian cellular receptors or transporters or both, including dopamine, serotonin or norepinephrine receptors or transporters, any combination of them, or all of them. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimers disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinsons disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilsons disease, and Tourettes syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the piperidine-piperazine compounds, and the screening of those libraries for biological activity, e. g. , in assays based on dopamine receptors or transporters or both.

Spirocyclic Ligands For Sigma Receptors, And Libraries And Methods Of Use Thereof

View page
US Patent:
6762177, Jul 13, 2004
Filed:
Nov 5, 2002
Appl. No.:
10/289119
Inventors:
Heike Radeke - Dedham MA
Paul E. Persons - Westborough MA
James R. Hauske - Concord MA
Assignee:
Sepracor, Inc. - Marlborough MA
International Classification:
C07D47110
US Classification:
51421208, 514278, 540522, 540543, 546 16, 546 18
Abstract:
One aspect of the present invention relates to spirocyclic compounds. Another aspect of the present invention relates to the use of the spirocyclic compounds as ligands for mammalian G-protein-coupled receptors or sigma receptors. The present invention also relates to methods of modulating the activity of a G-protein-coupled receptor or a sigma receptor in a mammal using the spirocyclic compounds of the present invention. The present invention also relates to methods of treating various diseases in a mammal using the spirocyclic compounds of the present invention.

Antipsychotic Sulfonamide-Heterocycles, And Methods Of Use Thereof

View page
US Patent:
6872716, Mar 29, 2005
Filed:
Jan 28, 2004
Appl. No.:
10/766300
Inventors:
Xinhe Wu - Marlborough MA, US
Brian M. Aquila - Marlborough MA, US
Liming Shao - Lincoln MA, US
Heike Radeke - Dedham MA, US
Gregory D. Cuny - Hudson MA, US
James R. Hauske - Concord MA, US
Roger L. Xie - Natick MA, US
Assignee:
Sepracor, Inc. - Marlborough MA
International Classification:
A61K031/44
C07D401/00
C07D211/00
US Classification:
514183, 514315, 514331, 514277, 514332, 514337, 514350, 514354, 514353, 514357, 514705, 514603
Abstract:
One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds comprising a sulfonamide moiety, and the screening of those libraries for biological activity, e. g. , in animal models of psychosis.

Piperidine-Piperazine Ligands For Neurotransmitter Receptors

View page
US Patent:
6936614, Aug 30, 2005
Filed:
Mar 24, 2004
Appl. No.:
10/808252
Inventors:
Paul E. Persons - Westborough MA, US
Heike Radeke - South Grafton MA, US
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K031/495
C07D401/06
US Classification:
51425301, 51425313, 544360
Abstract:
One aspect of the present invention relates to piperidine-piperazine compounds. A second aspect of the present invention relates to the use of the piperidine-piperazine compounds as ligands for various mammalian cellular receptors or transporters or both, including dopamine, serotonin or norepinephrine receptors or transporters, any combination of them, or all of them. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the piperidine-piperazine compounds, and the screening of those libraries for biological activity, e. g. , in assays based on dopamine receptors or transporters or both.

Spirocyclic Ligands For Sigma Receptors, And Libraries And Methods Of Use Thereof

View page
US Patent:
6992077, Jan 31, 2006
Filed:
Jul 13, 2004
Appl. No.:
10/890408
Inventors:
Heike Radeke - Dedham MA, US
Paul E. Persons - Westborough MA, US
James R. Hauske - Concord MA, US
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
C07D 471/04
C07D 221/00
C07D 223/00
A61K 31/438
A61K 31/55
US Classification:
51421208, 514278, 540522, 540543, 546 16, 546 18
Abstract:
One aspect of the present invention relates to spirocyclic compounds. Another aspect of the present invention relates to the use of the spirocyclic compounds as ligands for mammalian G-protein-coupled receptors or sigma receptors. The present invention also relates to methods of modulating the activity of a G-protein-coupled receptor or a sigma receptor in a mammal using the spirocyclic compounds of the present invention. The present invention also relates to methods of treating various diseases in a mammal using the spirocyclic compounds of the present invention.

1,4-Disubstituted Piperazine Ligands For Neurotransmitter Receptors

View page
US Patent:
7030122, Apr 18, 2006
Filed:
Mar 27, 2003
Appl. No.:
10/401106
Inventors:
James R. Hauske - Concord MA, US
Joanne M. Holland - Brookline MA, US
Heike S. Radeke - South Grafton MA, US
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K 31/497
A61K 31/4965
C07D 401/12
C07D 241/04
US Classification:
51425213, 51425503, 544238, 544360, 544359, 544400
Abstract:
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including serotonin receptors and dopamine receptors. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, Tourette's syndrome, psychiatric disorders, stroke, and senile dementia.
Control profile
Heike S Radeke from Apex, NC, age ~54 Get Report