Search

Heike Keilhack

from Belmont, MA
Get Report
Also known as:
H Keilhack
Phone and address:
3 Falmouth St APT 4, Belmont, MA 02478
Connected to:
Andrea S Keilholz, 40David L Keilholz, 68Kristy L Keilig, 53Scott M Keilin, 57Sharon M Keilin, 80Daniel J Keiling, 29Sara E Keiling, 42Tony B Keiling, 36Alyssa K Keill, 34Johnny T Keill, 34

Heike Keilhack Phones & Addresses

  • 3 Falmouth St APT 4, Belmont, MA 02478
  • 5 Boylston St, Jamaica Plain, MA 02130 (617) 522-6314
  • Roslindale, MA
  • 3 Falmouth St #4, Belmont, MA 02478 (617) 522-6314

Work

Company: Epizyme 2011 Address: Cambridge MA Position: Associate director

Education

Degree: Dipl. Biochem. School / High School: Martin-Luther-Universität Halle-Wittenberg 1991 to 1996 Specialities: Biochemistry

Skills

Drug Discovery • Cell Biology • Cell Culture • Drug Development • Life Sciences • Molecular Biology • Biotechnology • Pharmaceutical Industry • Biochemistry • Assay Development

Industries

Biotechnology

Resumes

Resumes

Heike Keilhack Photo 1

Senior Vice President Biological Sciences

View page
Location:
Belmont, MA
Industry:
Biotechnology
Work:
Epizyme - Cambridge MA since 2011
Associate Director
Merck 2006 - Jun 2011
Research Fellow
Serono Research Institute 2004 - 2006
Principal Investigator
Harvard Medical School 2000 - 2004
Postdoctoral Fellow
Education:
Martin-Luther-Universität Halle-Wittenberg 1991 - 1996
Dipl. Biochem., Biochemistry
Skills:
Drug Discovery
Cell Biology
Cell Culture
Drug Development
Life Sciences
Molecular Biology
Biotechnology
Pharmaceutical Industry
Biochemistry
Assay Development

Publications

Us Patents

Aryl- Or Heteroaryl-Substituted Benzene Compounds

View page
US Patent:
20130123234, May 16, 2013
Filed:
Dec 20, 2012
Appl. No.:
13/722807
Inventors:
EISAI R&D MANAGEMENT CO., LTD. - Tokyo, JP
Kenneth William Duncan - Norwood MA, US
Heike Keilhack - Belmont MA, US
Natalie Warholic - Brighton MA, US
Christine Klaus - Weymouth MA, US
Sarah Kathleen Knutson - Cambridge MA, US
Timothy James Nelson Wigle - Waltham MA, US
Masashi Seki - Tsukuba-shi, JP
Syuji Shirotori - Tsukuba-shi, JP
Satoshi Kawano - Tsukuba-shi, JP
Assignee:
EISAI R&D MANAGEMENT CO., LTD. - Tokyo
EPIZYME, INC. - Cambridge MA
International Classification:
C07D 213/64
C07D 401/12
C07D 491/08
C07D 417/12
C07D 491/107
C07D 405/14
C07D 409/12
US Classification:
51421018, 544131, 5142355, 544364, 51425311, 546194, 514318, 546300, 514351, 5462681, 5462727, 514341, 544405, 51425505, 540575, 514218, 5142102
Abstract:
The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Aryl- Or Heteroaryl-Substituted Benzene Compounds

View page
US Patent:
20120264734, Oct 18, 2012
Filed:
Apr 13, 2012
Appl. No.:
13/447007
Inventors:
KEVIN W. KUNTZ - WOBURN MA, US
RICHARD CHESWORTH - CONCORD MA, US
KENNETH W. DUNCAN - NORWOOD MA, US
HEIKE KEILHACK - BELMONT MA, US
NATALIE WARHOLIC - BRIGHTON MA, US
CHRISTINE KLAUS - WEYMOUTH MA, US
WANJUN ZHENG - LONDONDERRY NH, US
MASASHI SEKI - TSUKUBA, JP
SYUJI SHIROTORI - TSUKUBA, JP
SATOSHI KAWANO - TSUKUBA, JP
International Classification:
A61K 31/4427
C07D 413/12
C07D 401/12
C07D 401/14
C07D 405/14
C07D 413/14
A61K 31/4412
A61K 31/5377
A61K 31/444
A61K 31/4545
A61K 31/4439
A61K 31/4433
A61K 31/551
A61K 31/553
A61P 35/00
C07D 213/64
US Classification:
51421018, 546291, 544131, 546261, 546194, 5462754, 544130, 5462821, 540575, 540544, 514346, 5142355, 514335, 514318, 514341, 514336, 514218, 51421115, 5142102
Abstract:
The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Methods Of Treating Cancer

View page
US Patent:
20220315566, Oct 6, 2022
Filed:
Mar 8, 2022
Appl. No.:
17/689704
Inventors:
- Cambridge MA, US
Natalie WARHOLIC - Cambridge MA, US
Heike KEILHACK - Belmont MA, US
International Classification:
C07D 405/14
C07D 211/86
C07D 405/12
A61K 31/5377
C12Q 1/6886
A61K 31/4412
A61K 31/4545
Abstract:
The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Aryl-Or Heteroaryl-Substituted Benzene Compounds

View page
US Patent:
20210379076, Dec 9, 2021
Filed:
May 5, 2021
Appl. No.:
17/308610
Inventors:
- Cambridge MA, US
Richard CHESWORTH - Concord MA, US
Kenneth W. DUNCAN - Westwood MA, US
Heike KEILHACK - Belmont MA, US
Natalie WARHOLIC - Cambridge MA, US
Christine KLAUS - Waban MA, US
Sarah K. KNUTSON - Lincoln MA, US
Masashi SEKI - Tsukuba-shi, JP
Syuji SHIROTORI - Tsukuba-shi, JP
Satoshi KAWANO - Tsukuba-shi, JP
International Classification:
A61K 31/5377
C07D 498/08
C07D 401/12
C07D 405/12
C07D 409/12
C07D 413/12
C07D 417/12
C07D 491/08
C07D 491/107
C07D 213/64
C07D 405/14
A61K 31/4412
A61K 31/443
A61K 31/4433
A61K 31/4436
A61K 31/4439
A61K 31/444
A61K 31/4545
A61K 31/4709
A61K 31/496
A61K 31/506
A61K 31/551
A61K 31/553
Abstract:
The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Method For Treating Cancer

View page
US Patent:
20210267990, Sep 2, 2021
Filed:
Feb 4, 2021
Appl. No.:
17/167200
Inventors:
- Cambridge MA, US
Heike KEILHACK - Belmont MA, US
International Classification:
A61K 31/5377
A61K 45/06
A61K 31/45
A61K 31/453
A61P 35/00
A61P 37/00
Abstract:
The present invention provides a method for treating or alleviating a symptom of a disorder, e.g., immune evasion, cancer-cell induced immune dysfunction, reduced immune response, lowered inflammation, decreased expression of a major histocompatibility complex (MHC), or cancer, characterized by aberrant, misregulated, or increased Enhancer of Zeste Homolog 2 (EZH2) activity in a cell or subject in need thereof by contacting the cell or administering to the subject a therapeutically effective amount of an EZH2 inhibitor.

Method Of Treating Malignant Rhabdoid Tumor Of The Ovary (Mrto)/Small Cell Cancer Of The Ovary Of The Hypercalcemic Type(Sccoht) With An Ezh2 Inhibitor

View page
US Patent:
20210121470, Apr 29, 2021
Filed:
Sep 3, 2020
Appl. No.:
17/011132
Inventors:
- Cambridge MA, US
Heike KEILHACK - Belmont MA, US
International Classification:
A61K 31/5377
A61K 31/445
A61K 31/496
A61K 31/4412
A61K 31/501
A61P 35/00
A61K 31/44
A61K 31/4545
Abstract:
The disclosure provides a method of treating a malignant rhabdoid tumor in a subject in need thereof including administering to the subject a therapeutically-effective amount of an enhancer of a zeste homolog 2 (EZH2) inhibitor. In certain embodiments of this method the malignant rhabdoid tumor is small cell cancer of the ovary of the hypercalcemic type (SCCOHT) and the EZH2 inhibitor is tazemetostat (also known as Tazemetostat).

Methods Of Treating Cancer

View page
US Patent:
20200323865, Oct 15, 2020
Filed:
Feb 13, 2020
Appl. No.:
16/789815
Inventors:
- Cambridge MA, US
Heike KEILHACK - Belmont MA, US
Scott RIBICH - Lexington MA, US
International Classification:
A61K 31/5377
A61P 35/00
A61K 31/4412
A61K 9/00
A61K 31/551
A61K 31/553
A61K 31/496
G01N 33/574
A61K 31/4545
A61K 31/5386
A61K 31/4439
A61K 31/4433
A61K 45/06
Abstract:
The disclosure relates to a method for treating cancer comprising administering a therapeutically effective amount of an EZH2 inhibitor to a subject in need thereof, wherein the cancer is characterized by at least one cancer cell originating from a stem cell, a progenitor cell, or an immature cell and wherein the at least one cancer cell comprises one or more genetic lesion(s) that confer(s) dependence of the cancer cell on an EZH2 function. In certain embodiments, the EZH2 inhibitor of the disclosure is tazemetostat or a pharmaceutically acceptable salt thereof.

Methods Of Treating Cancer

View page
US Patent:
20200262823, Aug 20, 2020
Filed:
Jan 22, 2020
Appl. No.:
16/749073
Inventors:
- Cambridge MA, US
Natalie WARHOLIC - Cambridge MA, US
Heike KEILHACK - Belmont MA, US
International Classification:
C07D 405/14
A61K 31/4545
A61K 31/4412
C12Q 1/6886
A61K 31/5377
C07D 405/12
C07D 211/86
Abstract:
The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Control profile
Heike Keilhack from Belmont, MA Get Report