US Patent:
20060168683, Jul 27, 2006
Inventors:
Timothy Hey - Zionsville IN, US
Thomas Meade - Zionsville IN, US
Stephanie Burton - Indianapolis IN, US
Donald Merlo - Carmel IN, US
Qihua Cai - Westfield IN, US
Haley Moon - Fishers IN, US
Joel Sheets - Zionsville IN, US
Aaron Woosley - Fishers IN, US
Assignee:
Dow AgroSciences LLC - Indianapolis IN
International Classification:
A01H 1/00
C07K 14/415
C12N 15/82
C12N 5/04
US Classification:
800279000, 435419000, 435468000, 530370000
Abstract:
The subject invention relates to insecticidal toxin complex (“TC”) fusion proteins and to polynucleotides that encode these fusion proteins. The subject invention also includes polynucleotides that encode the subject TC fusion proteins, and vectors comprising said polynucleotides. In some embodiments, the invention provides a fusion protein comprising a Class A protein, a Class B protein, and a Class C TC protein fused together to form a single protein. In some other embodiments, the invention provides a fusion protein comprising a Class B and a Class C TC proteins fused together. In the latter embodiments, the BC or CB fusion protein can be used to enhance or potentiate the anti-insect activity of a “Toxin A” or Class A protein. Heretofore, there was no expectation that such fusion proteins would properly function and retain their activity when fused together. The subject invention advantageously reduces the number of genes needed to transform plants. Thus, the subject invention also includes plants, cells (bacterial and plant cells for example), and seeds that comprise said polynucleotides. Said plants can produce fusion proteins of the subject invention, which convey insect resistance to said plants. The subject invention also includes methods of controlling pests (preferably insects and other plant pests) with fusion proteins of the subject invention.
