US Patent:
20160017312, Jan 21, 2016
Inventors:
- New York NY, US
Shari Walcott - New York NY, US
Haiyang Lu - New York NY, US
Li Luo - New York NY, US
Menghua Yang - New York NY, US
Zahra Salehi - New York NY, US
International Classification:
C12N 9/99
A61K 39/02
A01N 63/00
Abstract:
The subject matter disclosed herein pertains to the modulation of a bacterial invasion switch and the subsequent use of the bacterium to vaccinate an organism. In one embodiment, the bacterial invasion switch is modulated by changing the proteolysis of ExoR protein. In another embodiment, a mutated bacterium produces a mutant ExoR protein that resists proteolysis.