Gustav H Dreier

6569672, May 27, 2003

Jan 21, 2000

09/489586

Gustav H. Dreier - Jefferson NY
Edwin A. Rudd - Salem NH
David J. Green - Winchester NH

BBI BioSeq, Inc. - MA

C12M 136

4352866, 4352887, 4352872, 422295, 422309

Methods and apparatus in which pressure provides precise control over the timing and preferably synchronization of chemical reactions, particularly enzymatic reactions.

43660380, Dec 28, 1982

Aug 4, 1980

6/175052

Susan D. Kearney - Weston MA
Gustav H. Dreier - Acton MA
Alan D. Cormier - Newburyport MA

Instrumentation Laboratory Inc. - Lexington MA

G01N 2730
B29C 500

204195M

A one-piece disposable electrode comprising a sealed chamber containing an electrolyte solution, silver-silver chloride conductor in the electrolyte solution in the chamber and a cast-in-place membrane essentially flush with an exterior wall of this chamber for exposure to a biological fluid whose ion content is to be measured.

42455090, Jan 20, 1981

Mar 16, 1979

6/021069

Dinesh I. Mody - Bedford MA
Carolyn Bergkvist - Plaistow NH
Gustav H. Dreier - Acton MA

Instrumentation Laboratory Inc. - Lexington MA

G01N 114

73423A

Sampling apparatus designed for aspirating, diluting and mixing a small sample of fluid in precise amounts and delivering the mixture to a scientific apparatus at a place remote from the place of aspiration. Operation of the device may be manual but is preferably automatic. The apparatus is designed to process a plurality of sample fluids with no cross-contamination between samples. In essence, the apparatus is a fluid handling system including a sample pick-up assembly in fluid communication with an automatic valve assembly having two operative positions. The automatic valve assembly is in fluid communication with a dilutor assembly having a sample pump and a diluent pump operable by a common means. A mixing and delivery assembly is also in fluid communication with the automatic valve assembly and includes a cup designed for bidirectional rotation with an annular space about the cup. A dispensing probe dispenses into the cup precise amounts of sample and diluent in a predetermined ratio to each other and, following rotation of the cup to achieve the mixture of sample and diluent, an aspirator probe enters the mixture and delivers an amount thereof to an adjacent scientific instrument.

50389580, Aug 13, 1991

Mar 2, 1990

7/487525

Gustav H. Dreier - Stoughton MA

Norfolk Scientific, Inc. - Norwood MA

B65D 5116
B01L 300

220366

A sealable vented microscale centrifuge tube for centrifuging samples at substantially atmospheric pressure, thus avoiding the danger of backpressure in the stoppered centrifuge tube which may expel the cap or shatter the tube during centrifugation. The device of the invention includes a container having a wall defining a cavity capable of holding a sample; a flange surrounding the cavity opening and possessing a hole; and a shell which surrounds the flange and which extends above and below its plane, and is attached to the flange rim, thus supporting the container within the shell. It additionally includes a removable cap which seals the cavity of the container. When the cavity of the container is sealed by the removable cap, air which would otherwise be compressed in the container is vented through the hole through the flange of the container and into the space between the container wall and the supporting shell.

39496155, Apr 13, 1976

May 13, 1974

5/469080

Bernard Stein - Andover MA
Gustav H. Dreier - Acton MA

Instrumentation Laboratory, Inc. - Lexington MA

G01N 114

73423A

A flush system for electrochemical analysis apparatus comprising a reservoir of flush solution, a flush chamber connected thereto and open at the top, and a sample entrance (probe) arranged for movement between an immersed position in the flush chamber and a sampling position removed from the flush chamber.

6036923, Mar 14, 2000

Oct 28, 1997

8/793213

James A. Laugharn - Winchester MA
Gustav H. Dreier - Jefferson NY
Edwin A. Rudd - Salem NH
David J. Green - Winchester MA

Bioseq, Inc - Woburn MA

C12Q 168
G01N 700
B01L 1100
C07H 2104

422 8213

Methods and apparatus in which pressure provides precise control over the timing and preferably synchronization of chemical reactions, particularly enzymatic reactions.

44588127, Jul 10, 1984

Aug 9, 1982

6/406538

Gustav H. Dreier - Acton MA
Larry Sorenson - Waltham MA

Instrumentation Laboratory, Inc. - Lexington MA

B04B 500
B65D 2508

206221

A durable, low cost, disposable, single test reagent package with plural compartments that maintain reagents separate during long term storage and permits combining of compartment contents without opening the vessel in a simple, rapid, and controlled manner includes a body component and an imperforate cooperating cover component. The body component defines a central compartment and an annular compartment surrounding the central compartment. Each compartment is upwardly open with annular ridge structure between the two compartments, and reagent material is stored in at least one of the compartments. The cooperating cover component has peripheral rim structure that is sealingly attached to cooperating rim structure of the body component to provide an hermetically sealed vessel, and includes integral depending annular seal structure for reclosable sealing engagement with the annular ridge structure of the body component and annular flexible web structure that permits movement of the seal structure between a position in sealing engagement with the annular ridge structure and an open position in which reagent material in the central compartment may be flowed under centrifugal force over the annular ridge into the annular compartment while the package remains sealed.

39604985, Jun 1, 1976

Aug 1, 1974

5/493786

Jerrold Zindler - Boston MA
Gustav H. Dreier - Acton MA

Instrumentation Laboratory, Inc. - Lexington MA

E03B 1100
F17D 100
G01N 2726
G01N 3316

23253R

A blood analysis system comprises a plurality of flow through measuring chambers, each of which has an associated measuring electrode system for producing an output signal as a function of a parameter of the blood sample in its measuring chamber; and a control device which in a first condition places the measuring chambers in fluid communication with the system inlet and in a second condition isolates the chambers to that the electrode systems may be calibrated concurrently and independently of one another.