US Patent:
20120207793, Aug 16, 2012
Inventors:
Kevin Ward - Richmond VA, US
Gary Huvard - Richmond VA, US
Everette Carpenter - Richmond VA, US
Gurbhagat Sandhu - Richmond VA, US
Robert Barbee - Richmond VA, US
Bruce Spiess - Richmond VA, US
International Classification:
A61K 33/40
A61K 9/14
A61P 17/02
A61K 9/00
Abstract:
Methods and compositions for the controlled and sustained release of peroxides or oxygen to aqueous environments (e.g. a patient's body or circulatory system, or for other applications) or non-aqueous environments, include a material coating or encapsulating hydrogen peroxide, inorganic peroxides or peroxide adducts. In the case of peroxide adducts, and particularly in one type of embodiment, the peroxide adducts should be able to permeate the material, but water, hydrogen peroxide and inorganic peroxides should be able to permeate the material. The methods and compositions that allow the release of oxygen, HOor inorganic peroxides from peroxide adducts with movement of these moieties across a selectively permeable barrier into, preferably, an aqueous environment. In the case of hydrogen peroxide, it can be acted upon by catalase or other enzymes, or be simply degraded, or are otherwise acted upon by enzymes or catalysts embedded in the selectively permeable barrier to produce, for example, O. Alternatively, hydrogen peroxide or inorganic peroxides can be delivered selectively to a site of action of cleaning, disinfecting or other applications.