Gregory Zeltser

20020103475, Aug 1, 2002

Jan 30, 2001

09/772702

John Bartha - Rancho Palos Verdes CA, US
Lehel Balint - Rancho Palos Verdes CA, US
Gregory Zeltser - Irvine CA, US
Arthur Bunzel - Laguna Beach CA, US
Yin Tang - Los Angeles CA, US

A61K009/22

604/891100

An implantable bioartificial active secretion system for providing a physiological secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host in fluidic communication with tissue fluid indicative of secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological secretion. A periodically operating pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the regulating physiological secretion for subsequent physiologically-effective dispensing into the host while avoiding immunorejection of the host body or of the host to the secretory cells.

20130289540, Oct 31, 2013

Mar 15, 2013

13/835655

Gregory Zeltser - Irvine CA, US
Michael Piliavin - Los Angeles CA, US

A61M 5/142

6048911

The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immunorejection of the host body or of the host to the secretory cells.

20150297828, Oct 22, 2015

Jun 29, 2015

14/753554

Gregory ZELTSER - Irvine CA, US
Michael PILIAVIN - Los Angeles CA, US

A61M 5/142
A61F 2/02

The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immuno-rejection of the host body or of the host to the secretory cells.