Gunter A. Kohler - Grant Township, Washington County MN
Gary M. Pestel - Mahtomedi MN
Minnesota Mining and Manufacturing Company - St. Paul MN
Chemical complexes, useful as radiopharmaceuticals, are formed by reacting technetium-99m with substituted or unsubstituted alkyl monophosphonic acids and certain ester derivatives thereof. The complexes are formed by reducing pertechnetate ion chemically or electrolytically in the presence of the phosphonic acid. By chemical modification of the phosphonic acid complexing agent, it is possible to "tailor" complexes for kidney, liver or bone imaging. The complexes are normally used in a physiologically acceptable aqueous medium.