US Patent:
20200407440, Dec 31, 2020
Inventors:
- Cambridge MA, US
Rajiv Panwar - Acton MA, US
Ganapathy N. Sarma - Belmont MA, US
Torsten Hechler - Ladenburg, DE
Michael Kulke - Ladenburg, DE
Andreas Pahl - Ladenburg, DE
Christoph Mueller - Ladenburg, DE
Werner Simon - Ladenburg, DE
Christian Lutz - Ladenburg, DE
Francesca Gallo - Ladenburg, DE
International Classification:
C07K 16/28
A61K 45/06
A61K 47/68
Abstract:
Amatoxins, as well as antibody-drug conjugates (ADCs) comprising an amatoxin are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, as well as prevention of graft-versus-host-disease (GVHD), are provided.
