Inventors:
Wen-Chih Liu - Princeton Junction NJ
William E. Brown - Princeton NJ
Gail L. Astle - Princeton NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
A61K 3500
C07H 1522
Abstract:
A method is provided for recovering a polyether antibiotic, such as lonomycin, monensin or ionomycin from a fermentation broth, wherein the polyether is first extracted with a water-immiscible solvent, such as ethyl acetate, and the resulting extracts concentrated, dissolved in aqueous methanol and then extracted into hexane, benzene or mixtures thereof. The polyether is thereby recovered in crystalline form directly from the latter extract.
