Inventors:
Simon H. Friedman - San Francisco CA
Raymond F. Schinazi - Decatur GA
Fred Wudl - Santa Barbara CA
Craig L. Hill - Atlanta GA
Diane L. DeCamp - Atlanta GA
Rintje P. Sijbesma - Eindhoven, NL
George L. Kenyon - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 3116
US Classification:
514256, 514278, 514378, 514400, 514406, 514532, 514563, 514569, 514574, 514616, 514623, 514648, 514654, 514655, 514661, 514691, 514766
Abstract:
A water soluble derivative of buckministerfullerene (C ) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.