Inventors:
Michael Hale - Bedford MA
Xiaoling Xie - Cambridge MA
Jeremy Green - Burlington MA
Jingrong Cao - Newton MA
Christopher Baker - Bedford MA
Francois Maltais - Somerville MA
James Janetka - Beverly MA
Guy Bemis - Arlington MA
Michael Mullican - Needham MA
Judith Straub - Cambridge MA
Qing Tang - Cambridge MA
Robert Mashal - West Newton MA
Assignee:
Vertex Pharmacuticals, Incorporated - Cambridge MA
International Classification:
A61K 315377
US Classification:
5142365, 540575, 544140, 544295, 544328, 544367, 544371, 544363, 546 86, 546146, 546199, 5462737, 5462754, 546211, 548127, 5483124, 5483641, 5483644, 5483657
Abstract:
Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R , Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.