US Patent:
20210015898, Jan 21, 2021
Inventors:
- Seattle WA, US
Jonathan Ting - Lake Forest Park WA, US
Boaz P. Levi - Seattle WA, US
Erik Hess - Issaquah WA, US
Franck Kalume - Bothell WA, US
Assignee:
ALLEN INSTITUTE - Seattle WA
SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE - Seattle WA
International Classification:
A61K 38/17
A61K 48/00
A61K 9/00
C12N 15/86
C07K 14/705
Abstract:
Selectively providing voltage-gated sodium channel function sufficient to rescue impaired Nav1.1 function to inhibitory neurons is described. Provided voltage-gated sodium channel function sufficient to rescue impaired Nav1.1 function in inhibitory neurons can be used to treat disorders such as epilepsy, and more particularly, Dravet Syndrome.