Francis E. Desposato - Kalamazoo MI Edward J. Hessler - Kalamazoo MI
Assignee:
The Upjohn Company - Kalamazoo MI
International Classification:
C07H 1708 A61K 3170
US Classification:
536 9
Abstract:
A rapid and efficient process for preparing the useful antibiotic erythromycin ethyl succinate in high yield which comprises reacting erythromycin USP quality free base with ethyl succinyl chloride in a two phase system consisting of an organic solvent which is capable of forming two phases with water or an aqueous base, and an aqueous base.