Inventors:
John P. Carulli - Southborough MA, US
Peter K. Gregersen - Larchmont NY, US
Franak Batliwalla - Port Washington NY, US
Jadwiga Bienkowska - Cambridge MA, US
Chunyu Liu - Sharon MA, US
Assignee:
Biogen Idec MA Inc. - Cambridge MA
The Feinstein Institute for Medical Research - Manhasset NY
International Classification:
A61K 39/395
C12Q 1/68
G01N 33/564
G01N 33/68
C40B 40/08
A61K 31/60
A61K 38/13
A61K 31/7105
A61P 29/00
US Classification:
4241341, 435 6, 436506, 435 78, 506 17, 514165, 4241581, 514 205, 514 44 A, 4241331, 4241421
Abstract:
The present disclosure provides biomarkers that are predictive a subject's responsiveness or non-responsiveness to an anti-TNF therapy. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities (e.g., an anti-TNF therapy or a non-anti-TNF therapy) for a subject suffering from a disease such as an immune disorder.