US Patent:
20090124601, May 14, 2009
Inventors:
Zhiguo J. Song - Edison NJ, US
Fei Zhang - Edison NJ, US
Rebecca Leigh Shultz - Maplewood NJ, US
International Classification:
A61K 31/551
C07D 223/10
Abstract:
Tartaric acid salts of (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl) butanoyl]hexahydro-3-(2,2,2-trifluoroethyl)-2H-1,4-diazepin-2-one are potent inhibitors of dipeptidyl peptidase-IV and are useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as Type 2 diabetes. The invention also relates to crystalline anhydrate forms of the tartaric acid salts as well as a process for their preparation, pharmaceutical compositions containing these novel forms and methods of use for the treatment of Type 2 diabetes.