Farouc A Jaffer

20100092389, Apr 15, 2010

Oct 10, 2008

12/249715

Farouc A. Jaffer - Jamaica Plain MA, US

The General Hospital Corporation - Boston MA

A61K 49/00
A61B 6/00

424 92, 424 91, 424 96, 600431

Exemplary embodiments of apparatus and method can be provided for imaging a portion of an anatomical structure. According to an exemplary embodiment of the present invention, an indocyanine green (ICG) agent can be provided to at least one portion of an anatomical structure, and it can be determined whether at least one plaque structure associated with the at least one portion includes at least one of an angiogenesis or an inflammation based on the interaction between the ICG agent and the at least one portion.

20100268070, Oct 21, 2010

Nov 24, 2009

12/625264

Farouc Jaffer - Jamaica Plain MA, US
Milind Rajopadhye - Westford MA, US

A61B 5/05
A61F 2/82

600425, 623 146

The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.

20110137140, Jun 9, 2011

Jul 14, 2010

12/835920

Guillermo J. TEARNEY - Cambridge MA, US
Melissa SUTER - Cambridge MA, US
Brett E. BOUMA - Quincy MA, US
Farouc A. JAFFER - Jamaica Plain MA, US

The General Hospital Corporation - Boston MA

A61B 5/02

600310

Exemplary embodiments of apparatus, system and method can be provided to measure a flow of fluid within an anatomical structure. For example, it is possible to use at least one first probe arrangement structured to be insertable into a vessel and configured to direct at least one radiation to at least one portion of the anatomical structure. Further, it is possible to provide at least one second arrangement which configured to detect an interference between a first radiation provided from the fluid via the probe arrangement and second a second radiation provided from a reference path as a function of wavelength thereof. Further, at least one third arrangement can be provided which is configured to determine at least one characteristic of the fluid as a function of the interference.

20120101374, Apr 26, 2012

May 24, 2011

13/114845

Guillermo J. Tearney - Cambridge MA, US
Brett Eugene Bouma - Quincy MA, US
Hongki Yoo - Melrose MA, US
Milen Shishkov - Watertown MA, US
Joseph Gardecki - Marlborough MA, US
Theodore Morse - Little Compton RI, US
Farouc Amin Jaffer - Jamaica Plain MA, US

The General Hospital Corporation - Boston MA

A61B 6/00

600427, 600425

Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

20090192358, Jul 30, 2009

Jan 28, 2008

12/020765

Farouc A. Jaffer - Jamaica Plain MA, US
Vasilis Ntziachristos - Cambridge MA, US

The General Hospital Corporation - Boston MA

A61B 1/07

600182

Apparatus and method can be provided for obtaining information regarding at least one portion of a biological structure. For example, using a first arrangement, it is possible to generate a first electro-magnetic radiation to be forwarded to the portion and receive, from the portion, a second fluorescent radiation associated with the first electro-magnetic radiation Further, using a second arrangement, it is possible to obtain information associated with the second fluorescent radiation, and generate at least one image of the portion as a function of the second fluorescent radiation. According to an exemplary embodiment of the present invention, the first arrangement can be inserted into at least one lumen, and the image of the portion may be associated with the at least one lumen.

20210267460, Sep 2, 2021

Mar 3, 2021

17/191343

- Boston MA, US
Hongki Yoo - Melrose MA, US
Milen Shishkov - Watertown MA, US
Joseph Gardecki - Acton MA, US
Roman Shubochkin - Arlington MA, US
Theodore Morse - Little Compton RI, US
Farouc Amin Jaffer - Jamaica Plain MA, US

A61B 5/00
G01N 21/65
G01B 9/02
G01N 21/64

Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

20210153840, May 27, 2021

Jun 4, 2019

15/734622

- Boston MA, US
Vasilis Ntziachristos - Graefelfing, DE
Dmitry Bozhko - Munich, DE
Farouc Jaffer - Jamaica Plain MA, US

A61B 8/12
A61B 8/00
A61B 8/08

A hybrid NIRF/IVUS imaging probe containing i) a spatially-truncated optical lens a substantially-planar surface of which is inclined with respect to an axis to reflect light, transmitted between proximal and distal ends of the probe, internally into a body of the lens, and ii) an acoustic transducer disposed sequentially with the optical lens on the axis of the probe while, at the same time, the optical and electrical members of the probe transmitting the radiative and mechanical energies (which the probe exchanges with a target bodily vessel) are parallel to one another within the housing of the probe. A method for operating the probe resulting in formation of spatially co-registered optical and acoustic images of the target. Related imaging system and computer-program product.

20170135584, May 18, 2017

Nov 22, 2016

15/359279

- Boston MA, US
Hongki Yoo - Melrose MA, US
Milen Shishkov - Watertown MA, US
Joseph Gardecki - Acton MA, US
Roman Shubochkin - Arlington MA, US
Theodore Morse - Little Compton RI, US
Farouc Amin Jaffer - Jamaica Plain MA, US

A61B 5/00
G01B 9/02
G01N 21/65
G01N 21/64

Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.