Inventors:
Richard J. Massey - Rockville MD
Mark T. Martin - Bethesda MD
Liwen Dong - Rockville MD
Ming Lu - Lanham MD
Alan Fischer - Cambridge MA
Fabian Jameison - Gaithersburg MD
Pam Liang - Rockville MD
Robert Hoch - Hensonville NY
Jonathan K. Leland - Silver Spring MD
Assignee:
Meso Scale Technologies, LLC - Gaithersburg MD
International Classification:
G01N 33551
US Classification:
436526, 435 6, 435 74, 435 75, 435 792, 435 793, 435 794, 435 24, 435 26, 435176, 435182, 436524, 436535, 436806, 5303911, 5303913, 5303915
Abstract:
Graphitic nanotubes, which include tubular fullerenes (commonly called âbuckytubesâ) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.