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Ezra S Abrams

from West Newton, MA
Age ~68
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Related to:
Maria R Nunez, 87Claribel Munez, 47Francis R Ricard, 61
Connected to:
Al Abrams, 63Alan M Abrams, 63Albert N Abrams, 76Alexa R Abrams, 33Alma R Abrams, 88Amy Abrams, 54Andie Abrams, 32Andre D Abrams, 52Angie B Abrams, 52Apollo R Abrams, 33

Ezra Abrams Phones & Addresses

  • 4 Colbert Rd, West Newton, MA 02465 (617) 527-6413
  • Newton, MA
  • Somerville, MA
  • Boston, MA
  • 4 Colbert Rd, West Newton, MA 02465 (617) 785-4737

Work

Company: Sage science, inc. Apr 2010 Position: Director of research

Skills

Biotechnology

Industries

Biotechnology

Resumes

Resumes

Ezra Abrams Photo 1

Director Of Research

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Location:
4 Colbert Rd, Newton, MA 02465
Industry:
Biotechnology
Work:
Sage Science, Inc.
Director of Research
First Light Biosciences Mar 2006 - Feb 2010
Principal Scientist
Matrix Technologies 2001 - 2006
Director of New Technology
Praecis Pharmaceuticals/Glaxo Smith Kline 1990 - 1994
Senior Scientist
Skills:
Biotechnology

Publications

Us Patents

Solid Phase Methods For Amplifying Multiple Nucleic Acids

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US Patent:
20020132245, Sep 19, 2002
Filed:
Oct 3, 2001
Appl. No.:
09/969990
Inventors:
T. Boles - Lexington MA, US
Ezra Abrams - Newton MA, US
Assignee:
Mosaic Technologies, Inc. - Waltham MA
International Classification:
C12Q001/68
C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
A multi-stage bridge amplification method which uses a recovered single-stranded amplification single-stranded nucleic acid molecule to initiate second and subsequent stages of bridge amplification is described.

Methods And Apparatus For Separating And Detecting Nucleic Acid

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US Patent:
20030138774, Jul 24, 2003
Filed:
Jan 19, 2001
Appl. No.:
09/766880
Inventors:
Chris Jones - Riverdale NJ, US
Ezra Abrams - Newton MA, US
Stephen Kieffer-Higgins - Dorchester MA, US
Tianhong Zhang - Ashland MA, US
Graham Eacock - Westborough MA, US
Michael Webb - Dunstable MA, US
Christopher McDowell - Maynard MA, US
International Classification:
C12Q001/68
G01N033/53
US Classification:
435/006000, 435/007100, 204/461000
Abstract:
A thin gel for separating and detecting a target molecule, (e.g., an analyte) and methods of use thereof is described. The gel can be optionally reinforced to facilitate removal from an electrophoretic apparatus, wherein the gel matrix comprises immobilized (e.g., covalently bound) capture probes capable of specifically hybridizing with, or binding to, the analyte to be detected. The gel is thin and very short assay times can be achieved facilitating rapid detection of analytes. An assay apparatus is suitable for use with an electrophoretic assay system for the detection of, or separation and detection of an analyte in a biological sample is also described.

Slotted Electrophoresis Gel Composition And Methods Of Use Thereof

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US Patent:
20030170635, Sep 11, 2003
Filed:
Mar 1, 2002
Appl. No.:
10/087221
Inventors:
Philip Hammond - Brighton MA, US
Christopher Adams - Somerville MA, US
Ezra Abrams - West Newton MA, US
T. Boles - Waltham MA, US
Assignee:
EXACT Sciences Corporation
International Classification:
C12Q001/68
G01L001/20
US Classification:
435/006000, 204/461000
Abstract:
A slotted electrophoresis gel composition and methods of use are disclosed in the present invention. The invention also describes an apparatus that is used to produce a slotted electrophoresis gel composition.

Method For Detecting Analytes

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US Patent:
20120149007, Jun 14, 2012
Filed:
Sep 24, 2009
Appl. No.:
13/120516
Inventors:
Ezra Abrams - Newton MA, US
Sadanand Gite - Arlington MA, US
Lisa Shinefeld - Lexington MA, US
Don Straus - Cambridge MA, US
Gordon Siek - Somerville MA, US
Greg Yantz - Somerville MA, US
Assignee:
Straus Holdings Inc. - Bedford MA
International Classification:
G01N 21/64
US Classification:
435 5, 435 615, 436501, 435 732
Abstract:
The invention provides an improved method for sensitive and specific detection of target molecules, cells, or viruses. The inventive method uses large area imaging to detect individual labeled targets complexed with a target-specific selection moiety. The invention eliminates wash steps through the use of target-specific selection through one or more liquid layers that can contain optical dye and density agents. By eliminating washes the invention simplifies instrumentation engineering and minimizes user steps and costs. The invention uses sensitive image analysis to enumerate individual targets in a large area, is scalable, and can be deployed in systems ranging in complexity from manual to highly automated.

Solid Phase Methods For Amplifying Multiple Nucleic Acids

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US Patent:
63000709, Oct 9, 2001
Filed:
Jun 4, 1999
Appl. No.:
9/327083
Inventors:
T. Christian Boles - Waltham MA
Ezra S. Abrams - Newton MA
Assignee:
Mosaic Technologies, Inc. - Waltham MA
International Classification:
C12Q 168
C12P 1934
C07H 2102
C07H 2104
C12N 1500
US Classification:
435 6
Abstract:
A multi-stage bridge amplification method which uses a recovered single-stranded amplification single-stranded nucleic acid molecule to initiate second and subsequent stages of bridge amplification is described.

Multiple Sequential Polynucleotide Displacement Reactions For Signal Amplification And Processing

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US Patent:
62550519, Jul 3, 2001
Filed:
Nov 6, 1998
Appl. No.:
9/188086
Inventors:
Philip W. Hammond - Brighton MA
Ezra S. Abrams - West Newton MA
T. Christian Boles - Waltham MA
Andrew R. Muir - Cohasset MA
Assignee:
Mosaic Technologies Inc. - Waltham MA
International Classification:
C07H 2104
C07H 1904
US Classification:
435 6
Abstract:
Methods for determining the presence of a target polynucleotide sequence using chemical hybridization in sequential probe and displacement complex formation with potential for signal gain prior to detection are disclosed.

Preparative Electrophoretic Method For Targeted Purification Of Genomic Dna Fragments

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US Patent:
20210207122, Jul 8, 2021
Filed:
Nov 21, 2016
Appl. No.:
15/777577
Inventors:
Robi David Mitra - Fenton MO, US
Jeffrey Milbrandt - St. Louis MO, US
Ezra S. Abrams - Newton MA, US
Todd J. Barbera - Marblehead MA, US
T. Christian Boles - Bedford MA, US
- Beverly MA, US
- St. Louis MO, US
Assignee:
Sage Science, Inc. - Beverly MA
Washington University - St. Louis MO
International Classification:
C12N 15/10
G01N 27/447
Abstract:
A sample containing particles having high-molecular-weight (HMW) DNA is entrapped in a gel matrix, and the gel matrix is exposed to a lysis reagent configured to release the HMW DNA from the particles. The HMW DNA may be purified by subjecting the gel matrix to an electrophoretic field that removes the HMW DNA from the particles, lysis reagents, and/or other sample constituents, from the gel matrix such that the HMW DNA remains. The gel matrix may be subjected with DNA cleavase reagents configured to cleave at specific DNA sequences within the HMW DNA to liberate defined segments of the DNA as fragments of reduced size. The gel matrix may also be subjected to an electrophoretic field, which moves and separates the DNA fragments from uncleaved DNA of the HMW DNA, which remains substantially immobile. The electrophoretically separated DNA fragments may be isolated from the gel matrix.

Methods And Systems For Controlling The Shear Modulus Of Genomic Length Dsdna Molecules

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US Patent:
20170239658, Aug 24, 2017
Filed:
Oct 16, 2015
Appl. No.:
15/519515
Inventors:
Ezra S. ABRAMS - Newton MA, US
Christian T. BOLES - Bedford MA, US
Yu CHEN - Princeton NJ, US
James STURM - Priceton NJ, US
Robert AUSTIN - Princeton NJ, US
- Beverly MA, US
- Princeton NJ, US
International Classification:
B01L 3/00
G01N 27/447
G01N 15/14
C12Q 1/68
Abstract:
In some embodiments, a method for manipulating DNA molecules for use in a microfluidic device is provided, where the method may comprise providing a solution of a plurality of DNA molecules having a first radius of gyration under under a zero flow velocity, and maintaining the DNA molecules in a spherical shape under a flow velocity.
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Ezra S Abrams from West Newton, MA, age ~68 Get Report