Eugene Y Chan

6355420, Mar 12, 2002

Aug 13, 1998

09/134411

Eugene Y. Chan - Brookline MA

US Genomics - Woburn MA

C12Q 168

435 6, 435 94, 435149, 4352871, 4352872, 435970, 435973

Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers.

6403311, Jun 11, 2002

Aug 13, 1999

09/374415

Eugene Y. Chan - Boston MA

US Genomics - Woburn MA

C12Q 168

435 6, 435375, 435 5, 2041828, 935 77, 935 78, 436 94, 548416, 549382, 546 33

The invention relates to methods and products for analyzing polymers. The polymers are analyzed by reconstructing sequence information from population data sets. The data sets include information about polymer dependent impulses arising from the polymers. The invention is also a method for linearly analyzing polymers by assessing the intensity of a signal arising from the polymer. The signal is generated as units and/or units specific markers pass a fixed station. The quantitative intensity of the signal is proportional to the number of units and/or unit specific markers giving rise to the signal.

6762059, Jul 13, 2004

Feb 14, 2001

09/783472

Eugene Y. Chan - Brookline MA
Lance C. Gleich - Somerville MA
Parris S. Wellman - Hillsborough NJ

U.S. Genomics, Inc. - Woburn MA

G01N 2101

436164, 436 86, 436 94, 436172, 435 6

The present invention relates to methods and apparatuses for characterization of single polymers. In particular, the invention relates to methods and apparatuses for determination of the velocities of single elongated polymers. Center-of-mass velocity, center-to-center velocity, end-to-end velocity and rise-time velocity are determined using time-correlated measurements of single elongated polymers in two or more detection zones. The invention also relates to methods of determinating lengths and molecular masses of single polymers and to methods of determining the distance between landmarks on a single polymers based on their velocities. The invention further relates to methods of single-molecule DNA restriction fragment analysis.

6772070, Aug 3, 2004

Feb 15, 2001

09/783930

Rudolf Gilmanshin - Waltham MA
Eugene Y Chan - Boston MA

U.S. Genomics, Inc. - Woburn MA

G06F 1900

702 19, 435 6

The present invention relates to methods and apparatuses for analyzing molecules, particularly polymers, and molecular complexes with extended or rod-like conformations. In particular, the methods and apparatuses are used to identify repetitive information in molecules or molecular ensembles, which is interpreted using an autocorrelation function in order to determine structural information about the molecules. The methods and apparatuses of the invention are used for, inter alia, determining the sequence of a nucleic acid, determining the degree of identity of two polymers, determining the spatial separation of specific sites within a polymer, determining the length of a polymer, and determining the velocity with which a molecule penetrates a biological membrane.

6790671, Sep 14, 2004

Aug 13, 1999

09/373822

Robert H. Austin - Princeton NJ
Jonas O. Tegenfeldt - Princeton NJ
Eugene Y. Chan - Boston MA

Princeton University - Princeton NJ

C12Q 168

436172, 436 94, 436164, 436177, 422 8201, 422 8205, 422 8208, 422 8212, 204155, 204603, 2504581, 2504611, 2504612, 356344, 435 6, 435808

The invention relates to new systems, methods and products for analyzing polymers and in particular new systems, methods and products useful for obtaining sequence information from polymers. The invention has numerous advantages over prior art systems and methods used to obtain sequence-related information. Using the methods of the invention the entire human genome could be analyzed several orders of magnitude faster than could be accomplished using conventional technology. In addition to obtaining sequencing information for the entire genome, the systems, methods and products of the invention can be used to create comprehensive and multiple expression maps for developmental and disease processes. The ability to analyze an individuals genome and to generate multiple expression maps will greatly enhance the ability to determine the genetic basis of any phenotypic trait or disease process.

6927065, Aug 9, 2005

Jun 6, 2001

09/875779

Eugene Y. Chan - Brookline MA, US
Lance C. Gleich - Somerville MA, US
Parris S. Wellman - Hillsborough NJ, US

U.S. Genomics, Inc. - Woburn MA

G01N021/64

436 94, 436 56, 436 86, 436150, 436164, 436172

A method for determining the length and velocity of single elongated macromolecules is disclosed. In particular, the present invention relates to methods and apparatus for determining the velocity of elongated polymeric molecules moving relative to one or more detection stations, as well as to methods and apparatus for determining the length of such molecules and the distance between landmarks that may be present on such molecules. The invention makes use of time correlated measurements of signal amplitude profiles that result from interactions between each detection station and portions of each macromolecule.

7282330, Oct 16, 2007

Feb 5, 2004

10/773084

Xiaojian (David) Zhao - Westford MA, US
Jeffrey D. Randall - Canton MA, US
Bijit Kundu - Brookline MA, US
Jessica Kesty - Seabrook NH, US
Steven R. Gullans - Natick MA, US
Eugene Y. Chan - Boston MA, US
Martin Fuchs - Uxbridge MA, US
Jenny E. Rooke - Somerville MA, US

U.S. Genomics, Inc. - Woburn MA

C12Q 1/68
C07H 21/02
C07H 21/04

435 6, 536 231, 536 243

The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.

7371520, May 13, 2008

May 28, 2003

10/448264

Xiaojian (David) Zhao - Westford MA, US
Jeffrey D. Randall - Canton MA, US
Bijit Kundu - Brookline MA, US
Jessica Kesty - Seabrook NH, US
Steve R. Gullans - Natick MA, US
Eugene Y. Chan - Brookline MA, US
Martin Fuchs - Uxbridge MA, US

U.S. Genomics, Inc. - Woburn MA

C12Q 1/68
C07H 21/02
C07H 21/04

435 6, 536 231, 536 243

The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.