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Esteban A Roberts

from Tucson, AZ
Age ~49
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Also known as:
Esteba A Brady
Phone and address:
4760 W Snow Leopard Dr, Tucson, AZ 85742
(520) 400-1783
Related to:
John RobertsMary Elizabeth Roberts, 50Georgene K Brady, 79Astrid E Roberts, 80Lanett L Wilmshurst, 49Liza M Roberts, 53Charles M Brady, 78Richard Roberts, 56Kay BradyCarol Hogan, 51Stephen R Roberts, 75Deanna D Roberts, 49Brenda Brady, 54
Connected to:
Aaliyah R Robertson, 30Addie B Robertson, 105Adele Roberts, 71Adriana K Robertson, 37Afiya C Roberts, 32Agnes M Roberts, 81Aileen A Roberts, 45Ainsley N Roberts, 58Aj Robertson, 64Alesha Roberts, 43

Esteban Roberts Phones & Addresses

  • 4760 W Snow Leopard Dr, Tucson, AZ 85742 (520) 400-1783
  • 2950 W Tania Pl, Tucson, AZ 85741
  • 4279 N Howe Pl, Tucson, AZ 85705
  • Albuquerque, NM
  • 4760 W Snow Leopard Dr, Tucson, AZ 85742

Education

Degree: Associate degree or higher

Resumes

Resumes

Esteban Roberts Photo 1

Staff Scientist

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Location:
Tucson, AZ
Industry:
Research
Work:
Roche Molecular Systems Tissue Diagnostics
Manager, Strategic Applications
University of New Mexico Jun 2007 - Jul 2008
Senior Scientist Ii
Ventana Medical Systems Jun 2007 - Jul 2008
Staff Scientist
Education:
University of Arizona 1999 - 2004
Doctorates, Doctor of Philosophy, Microbiology, Immunology, Philosophy
Skills:
Biochemistry
Molecular Biology
Cell Biology
Immunohistochemistry
Assay Development
Genomics
Cell Culture
Protein Chemistry
Microscopy
Pcr
Fluorescence Microscopy
Biotechnology
Confocal Microscopy
Cancer
Cell
Lifesciences
Languages:
Spanish
Esteban Roberts Photo 2

Esteban Roberts

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Publications

Us Patents

Method For Tissue Sample Fixation

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US Patent:
20120214195, Aug 23, 2012
Filed:
Feb 13, 2012
Appl. No.:
13/372040
Inventors:
David Chafin - Tucson AZ, US
Abbey Pierson Theiss - Tucson AZ, US
Michael Otter - Tucson AZ, US
Esteban Roberts - Tucson AZ, US
International Classification:
G01N 1/30
US Classification:
435 4052
Abstract:
An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0 C. to at least 15 C. The second temperature typically is from greater than about 22 C. to about 55 C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.

Methods, Systems, And Apparatuses For Quantitative Analysis Of Heterogeneous Biomarker Distribution

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US Patent:
20210279870, Sep 9, 2021
Filed:
May 25, 2021
Appl. No.:
17/329966
Inventors:
- Tucson AZ, US
- Portland OR, US
Karl Garsha - Sahuarita AZ, US
Thomas M. Grogan - Tucson AZ, US
Esteban Roberts - Tucson AZ, US
Benjamin Stevens - Oro Valley AZ, US
Franklin Ventura - Tucson AZ, US
Kandavel Shanmugam - Chandler AZ, US
Joe Gray - Lake Oswego OR, US
Damien Ramunno-Johnson - Vancouver WA, US
Tothu Tania Vu - Portland OR, US
Brian J. Druker - Portland OR, US
Thomas Jacob - Beaverton OR, US
International Classification:
G06T 7/00
G06T 7/11
G06K 9/00
G06T 7/90
Abstract:
Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Methods And Systems For Preparing And Analyzing Cellular Samples For Morphological Characteristics And Biomarker Expression

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US Patent:
20210270704, Sep 2, 2021
Filed:
May 19, 2021
Appl. No.:
17/303092
Inventors:
- Tucson AZ, US
- Indianapolis IN, US
- Brighton MA, US
Katherine K. Mui - Chelmsford MA, US
Esteban Roberts - Tucson AZ, US
Noemi Sebastiao - Tucson AZ, US
David J. Zahniser - Wellesley MA, US
International Classification:
G01N 1/30
G01N 33/50
Abstract:
This disclosure relates generally to the use of automated platforms in the preparation of biomarker-stained cellular samples for microscopic analysis and use of such stained cells in the diagnosis of certain conditions. Disclosed herein is a method of affinity staining a Romanowsky-type stained sample on automated advanced staining systems, wherein the automated advanced stainer destains the sample prior to contact with a biomarker-specific reagent. Also disclosed herein are methods of processing body fluid samples for morphological and biomarker analysis by depositing cells of the sample in a thin layer onto one or more solid supports, staining at least one such solid support with a Romanowsky-type stain and staining at least one such solid support for one or more biomarkers useful for categorizing one or more cells of the sample.

Method Of Identifying Treatment Responsive Non-Small Cell Lung Cancer Using Anaplastic Lymphoma Kinase (Alk) As A Marker

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US Patent:
20200225237, Jul 16, 2020
Filed:
Mar 13, 2020
Appl. No.:
16/818809
Inventors:
- Tucson AZ, US
June F. Clements - Tucson AZ, US
Thomas Grogan - Tucson AZ, US
Hiro Nitta - Tucson AZ, US
Esteban Roberts - Tucson AZ, US
Crystal Schemp - Tucson AZ, US
Shalini Singh - Tucson AZ, US
Penny Towne - Tucson AZ, US
International Classification:
G01N 33/574
A61K 31/4545
Abstract:
Disclosed herein are methods for identifying a subject as having NSCLC that is predicted or is likely to respond to treatment with an ALK inhibitor, for example crizotinib. The methods include identifying a sample including NSCLC tumor cells as ALK-positive or ALK-negative using immunohistochemistry (IHC) and scoring methods disclosed herein. A subject is identified as having NSCLC likely to respond to treatment with an ALK inhibitor if the sample is identified as ALK-positive and is identified as having NSCLC not likely to respond to treatment with an ALK inhibitor if the sample is identified as ALK-negative. According to certain embodiments of the methods, subjects predicted to respond to an ALK inhibitor may then be treated with an ALK inhibitor such as crizotinib.

Methods, Systems, And Apparatuses For Quantitative Analysis Of Heterogeneous Biomarker Distribution

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US Patent:
20200219256, Jul 9, 2020
Filed:
Mar 6, 2020
Appl. No.:
16/811688
Inventors:
- Tucson AZ, US
- Portland OR, US
Karl Garsha - Sahuarita AZ, US
Thomas M. Grogan - Tucson AZ, US
Esteban Roberts - Tucson AZ, US
Benjamin Stevens - Oro Valley AZ, US
Franklin Ventura - Tucson AZ, US
Kandavel Shanmugam - Chandler AZ, US
Joe Gray - Lake Oswego OR, US
Damien Ramunno-Johnson - Vancouver WA, US
Tothu Tania Vu - Portland OR, US
Brian J. Druker - Portland OR, US
Thomas Jacob - Beaverton OR, US
International Classification:
G06T 7/00
G06T 7/11
G06T 7/90
G06K 9/00
Abstract:
Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Representative Diagnostics

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US Patent:
20200049599, Feb 13, 2020
Filed:
Apr 27, 2018
Appl. No.:
15/965786
Inventors:
- Tucson AZ, US
Aoune Barhoumi - Tucson AZ, US
Melinda Day - Oro Valley AZ, US
Lisa Gallegos - Tucson AZ, US
Katherine Leith - Tucson AZ, US
Samantha Rajkovich - Marana AZ, US
Esteban Roberts - Tucson AZ, US
Stacey Stanislaw - Tucson AZ, US
Eric Walk - Tucson AZ, US
International Classification:
G01N 1/28
A01N 1/02
G01N 33/483
G01N 1/30
G01N 1/36
Abstract:
The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.

System, Method And Kit For Sample Preparation

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US Patent:
20190234842, Aug 1, 2019
Filed:
Apr 5, 2019
Appl. No.:
16/376001
Inventors:
- Tucson AZ, US
CHRISTOPHER LAWRENCE DONAT - TUCSON AZ, US
MELIS HAZAR - TUCSON AZ, US
ESTEBAN ROBERTS - TUCSON AZ, US
MOHAMED A. SAKR - PHILADELPHIA PA, US
International Classification:
G01N 1/31
B01L 3/00
Abstract:
A system, method and kit for preparing a cellular biological sample are disclosed. In a particular embodiment, the disclosed system () is configured to mate with a substrate (), such as a microscope slide, and provide the fluidics that can be used to perform a particular sample preparation protocol. The disclosed system is particularly suited for use in a point-of-care setting, such as in a surgical suite or in a resource-limited or remote setting where automation of the sample preparation protocol is not a viable alternative.

Method For Tissue Sample Fixation

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US Patent:
20190086300, Mar 21, 2019
Filed:
Jan 22, 2018
Appl. No.:
15/877277
Inventors:
- Tucson AZ, US
Abbey Pierson Theiss - Tucson AZ, US
Michael Otter - Tucson AZ, US
Esteban Roberts - Tucson AZ, US
International Classification:
G01N 1/30
G01N 1/31
Abstract:
An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0 C. to at least 15 C. The second temperature typically is from greater than about 22 C. to about 55 C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.
Control profile
Esteban A Roberts from Tucson, AZ, age ~49 Get Report