Search

Eric G Mayhew

from Coupeville, WA
Age ~86
Get Report
Also known as:
Eric E Mayhew, Eric Nayhew
Phone and address:
1782 Seaview Ave, Coupeville, WA 98239
(206) 890-4364
Related to:
Matthew Robert Franklin, 56Christopher R Holmes, 37Karen A Mayhew, 70Ludmila Y Mayhew, 77Andrea A Mayhew, 41Kara Welber, 52Ian Mayhew, 46
Connected to:
Andre Mayhew, 53Anna K Mayhew, 52Britt D Mayhew, 45Charmaine Mayhew, 44Chester L Mayhew, 114Clifford B Mayhew, 63Codie L Mayhew, 40Erika Mayhew, 38Faye A Mayhew, 65Hannah Mayhew, 62

Eric Mayhew Phones & Addresses

  • 1782 Seaview Ave, Coupeville, WA 98239 (206) 890-4364
  • 3905 Bertona St, Seattle, WA 98199
  • Monmouth Junction, NJ
  • South Wales, NY
  • Capitan, NM
  • East Aurora, NY
  • Eatontown, NJ
  • 1782 Seaview Ave, Coupeville, WA 98239

Resumes

Resumes

Eric Mayhew Photo 1

Owner

View page
Location:
Coupeville, WA
Industry:
Research
Work:
Maypharm Consulting
Owner
The Liposome Company Sep 1993 - Sep 1999
Principal Scientist
Roswell Park Cancer Institute May 1964 - Sep 1993
Principal Cancer Research Scientist
Education:
University of London 1993
Doctorates, Doctor of Science University of London 1963 - 1967
Doctorates, Doctor of Philosophy, Philosophy University of London 1960 - 1963
Master of Science, Masters University of London 1956 - 1960
Bachelors, Bachelor of Science, Zoology, Chemistry Latymer Upper School 1949 - 1956
Skills:
Cell
Cancer Research
Cancer
Pharmacology
Drug Delivery
Pharmaceutics
Patents
Liposomes
Medical Research
R&D
Lifesciences
Biotechnology
Entrepreneurship
Technology Transfer
Product Development
Science
Biochemistry
Research
Molecular Biology
Pharmaceutical Industry
Eric Mayhew Photo 2

Eric Mayhew

View page
Eric Mayhew Photo 3

Eric Mayhew

View page
Eric Mayhew Photo 4

Eric Mayhew

View page

Publications

Us Patents

Hydrolysis-Promoting Hydrophobic Taxane Derivatives

View page
US Patent:
6392063, May 21, 2002
Filed:
Jul 19, 2000
Appl. No.:
09/618872
Inventors:
Shaukat Ali - Monmouth Junction NJ
J. Craig Franklin - Skillman NJ
Imran Ahmad - Cranbury NJ
Eric Mayhew - Monmouth Junction NJ
Soumendu Bhattacharya - Plainsboro NJ
Gil Koehane - Piscataway NJ
Andrew S. Janoff - Yardley PA
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
C07D30514
US Classification:
549510, 549511
Abstract:
Provided herein is a taxane having a hydrocarbon attached at the 2â and/or 7 positions, the hydrocarbons alpha position being occupied by a âhydrolysis-promoting groupâ (âHPGâ). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the a-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.

Hydrolysis-Promoting Hydrophobic Taxane Derivatives

View page
US Patent:
6482850, Nov 19, 2002
Filed:
Aug 29, 2001
Appl. No.:
09/940672
Inventors:
Shaukat Ali - Monmouth Junction NJ
J. Craig Franklin - Skillman NJ
Imran Ahmad - Cranbury NJ
Eric Mayhew - Monmouth Junction NJ
Soumendu Bhattacharya - Plainsboro NJ
Gil Koehane - Piscataway NJ
Andrew S. Janoff - Yardley PA
Assignee:
The Liposome Company - Princeton NJ
International Classification:
A01N 4302
US Classification:
514449, 549510, 549511
Abstract:
Provided herein is a taxane having a hydrocarbon attached at the 2â and/or 7 positions, the hydrocarbons alpha position being occupied by a âhydrolysis-promoting groupâ (âHPGâ). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the -carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.

Particulate Formulations

View page
US Patent:
6500461, Dec 31, 2002
Filed:
May 19, 1999
Appl. No.:
09/314338
Inventors:
Walter Perkins - Trenton NJ
Xingong Li - Levittown PA
Donald Hirsh - Trenton NJ
Eric Mayhew - Monmouth Junction NJ
Imran Ahmad - Cranbury NJ
Shaukat Ali - Monmouth Junction NJ
Andrew Janoff - Yardley PA
Assignee:
The Liposome Company - Princeton NJ
International Classification:
A61K 914
US Classification:
424489, 424427, 424434, 424435, 424436, 424490, 264 41, 264 43, 264 46
Abstract:
This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for a number of uses in animals, particularly the administration thereto of high concentrations of therapeutically useful compound, without an undue level of side effects.

Modified Ether Glyceroglycolipids

View page
US Patent:
6573246, Jun 3, 2003
Filed:
Aug 23, 2000
Appl. No.:
09/644470
Inventors:
Robert Bittman - Roslyn Heights NY
Ravi K. Erukulla - Plainsboro NY
Andrew C. Peters - Yardley PA
Eric G. Mayhew - Monmouth Junction NJ
Assignee:
The Liposome Company, Inc. - Princeton NJ
The Research Foundation of the City University of New York - New York NY
International Classification:
A61K 3170
US Classification:
514 25, 514 62, 536 41, 536 552
Abstract:
This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage, 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.

D And L Etherlipid Stereoisomers And Liposomes

View page
US Patent:
6667053, Dec 23, 2003
Filed:
Mar 31, 2000
Appl. No.:
09/540050
Inventors:
Imran Ahmad - Cranbury NJ
Eric Mayhew - Seattle WA
Andrew Janoff - Yardley PA
Assignee:
Elan Pharmaceuticals, Inc. - S. San Francisco CA
International Classification:
A61K 9133
US Classification:
424450, 4284022
Abstract:
A liposome having a lipid bilayer, where the lipid bilayer includes either the L or D stereoisomer of an ether lipid or a non-equal mixture of both. Most preferably the liposome also comprises (a) an underivatized phosphatidylcholine; (b) a sterol; (c) about 5-20 mole % of a phosphatidylethanolamine linked to a dicarboxylic acid at the ethanolamine group of the phosphatidylethanolamine, and (d) greater than about 10 mole % to less than about 30 mole % of either the L or D stereoisomer of an ether lipid. The liposome may be used as an anti-cancer or anti-inflammatory agent.

Etherlipid-Containing Multiple Lipid Liposomes

View page
US Patent:
RE39042, Mar 28, 2006
Filed:
Oct 11, 2001
Appl. No.:
09/976936
Inventors:
Eric Mayhew - Seattle WA, US
Andrew S. Janoff - Yardley PA, US
Imran Ahmad - Wadsworth IL, US
Suresh K. Bhatia - New Delhi, IN
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
A61K 9/127
US Classification:
424450, 4284022
Abstract:
Described herein are liposomes containing etherlipids of the formula: as well as a phosphatidylcholine, a sterol, and a headgroup-derivatized lipid. These liposomes are useful in a variety of therapeutic regimens, including the treatment of cancers and inflammatory disorders.

D And L Etherlipid Stereoisomers And Liposomes

View page
US Patent:
20040047903, Mar 11, 2004
Filed:
Aug 26, 2003
Appl. No.:
10/647382
Inventors:
Imran Ahmed - Cranbury NJ, US
Eric Mayhew - Seattle WA, US
Andrew Janoff - Yardley PA, US
Assignee:
ELAN PHARMACEUTICALS, INC.
International Classification:
A61K009/127
US Classification:
424/450000
Abstract:
A liposome having a lipid bilayer, where the lipid bilayer includes either the L or D stereoisomer of an ether lipid or a non-equal mixture of both. Most preferably the liposome also comprises (a) an underivatized phosphatidylcholine; (b) a sterol; (c) about 5-20 mole % of a phosphatidylethanolamine linked to a dicarboxylic acid at the ethanolamine group of the phosphatidylethanolamine, and (d) greater than about 10 mole % to less than about 30 mole % of either the L or D stereoisomer of an ether lipid. The liposome may be used as an anti-cancer or anti-inflammatory agent.

Hydrolysis-Promoting Hydrophobic Taxane Derivatives

View page
US Patent:
61073326, Aug 22, 2000
Filed:
Feb 12, 1999
Appl. No.:
9/249004
Inventors:
Shaukat Ali - Monmouth Junction NJ
J. Craig Franklin - Skillman NJ
Imran Ahmad - Cranbury NJ
Eric Mayhew - Monmouth Junction NJ
Soumendu Bhattacharya - Plainsboro NJ
Gil Koehane - Piscataway NJ
Andrew S. Janoff - Yardley PA
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
A61K 31337
C07D30514
US Classification:
514449
Abstract:
Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the. alpha. -carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.
Control profile
Eric G Mayhew from Coupeville, WA, age ~86 Get Report